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Sleep patterns can predict protein accumulation of Alzheimer's disease later in life, according to a new study of older men and women published in JNeurosci. These findings could lead to new early diagnosis and prevention measures based on sleep in the treatment of Alzheimer's disease.
Alzheimer's disease is badociated with sleep disturbance and an accumulation of tau and protein in the brain, which can occur long before the onset of characteristic memory disorders. Two types of sleep waves in the hippocampus, slow oscillations and spindles of sleep, are synchronized in young individuals, but it has been shown that old age lacked coordination.
Matthew Walker, Joseph Winer, and colleagues at the University of California at Berkeley found that a decrease in slow oscillations / synchronization of the sleep spindle was badociated with a higher tau, whereas the reduction in the amplitude of Slow wave activity was badociated with higher levels of β-amyloid.
The researchers also found that a decrease in the amount of sleep during aging, from the 50s to 70s, was badociated with higher levels of β-amyloid and tau later in life. This means that changes in brain activity during sleep and that the amount of sleep during these periods could serve as an alarm signal for Alzheimer's disease, thus enabling early preventative care.
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Manuscript Title: Sleep, potential biomarker of tau and β-amyloid charge in the human brain
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Sure JNeurosci
JNeurosci, the first journal of the Society for Neuroscience, was launched in 1981 to communicate the results of neuroscience research of the highest quality to the growing field. Today, the journal remains committed to the publication of cutting edge neuroscience that will have immediate and lasting scientific impact, while meeting the evolving publishing needs of authors, representing the breadth of the field and the diversity authors.
About the Society for Neuroscience
The Society for Neuroscience is the world's largest organization of scientists and doctors committed to understanding the brain and the nervous system. The non-profit organization, founded in 1969, now has nearly 37,000 members in more than 90 countries and more than 130 chapters worldwide.
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