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The University of Surrey has just shown that the benefits of "becoming viral" extend well beyond social media. A recent and exciting study focused on the use of catheters coxsackievirus (CVA21) administered to preoperative patients with noninvasive bladder cancer on muscle. The virus was administered one week prior to the planned tumor removal surgeries in all participants. Examination of postoperative tissue samples showed that CVA21 had aggressively labeled and attacked cancerous bladder cells, but had conveniently left healthy cells alone. As this type of bladder cancer is the 10th most common cancer in the UK, many health professionals see this encouraging data as a potential change in the tide of one of the most precarious demographic data of cancer.
The virus makes its effect by stimulating an immune protein within the cancer cells, which causes the other immune cells to participate in the evacuation of the cancerous element. Unlike all previous treatments badociated with non-invasive muscle bladder cancer, this approach is non-invasive and has not produced any side effects. Doctors generally consider that tumors of this type in the bladder are "cold" and therefore invisible to the immune system, but the introduction of the CVA21 virus seems to make them pbad to a "hot" reading, making the natural defenses of the body. react positively.
With its high recurrence rate, bladder cancer has not only stalled researchers seeking remedies for decades, but has also cost the NHS more than any other type of cancer ever recorded to date. Developments in progressive cancer therapies can often seem to ignore these more resilient brands of the disease, and so the CVA21 study data represents what many are touting as revolutionary, not just hopeful. All patients participating in this study recorded cancer cell death, and one of them found a total eradication of all symptoms of the disease. Medicinal immunotherapy treatments known as "checkpoint inhibitors" will now be badociated with CVA21 in the hope that further progress can be made towards a cure. Virus-based therapies have already shown promising success rates in skin cancer trials, and researchers are eager to apply them to large-scale trials based on other predominant cancer types.
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