[ad_1]
Dental caries is one of the most expensive and widespread bacterial diseases. Virulent bacteria cause acidification of tooth enamel and dentin, resulting in secondary tooth decay.
A new study by researchers at the Tel Aviv University has revealed potent antibacterial capabilities in new dental restoration products, or filling materials. According to research, resin-based composites, with the addition of antibacterial nano-bademblies, can hinder bacterial growth and viability of dental restorations, leading cause of recurrent caries, possibly leading to root cbad treatment and dental extractions.
The research for this study was led by Dr. Lihi Adler-Abramovich and TAU Ph.D. student Lee Schnaider, in collaboration with Prof. Ehud Gazit, prof. Rafi Pilo, prof. Tamar Brosh, Dr. Rachel Sarig and colleagues at the Maurice and Gabriela Goldschleger School of Dentistry at TAU and George S. Wise's Faculty of Life Sciences. It was published in ACS Applied Materials & Interfaces on May 28th.
"Antibiotic resistance is today one of the most urgent health problems facing society, and the development of new antimicrobial therapies and biomedical materials is an urgent unmet need," he said. said Adler-Abramovich. "When bacteria accumulate on the surface of the teeth, they eventually dissolve the hard tissues of the teeth, and recurrent caries – also known as secondary caries – are found in the margins of dental restorations and result from the production of acid by bacteria causing cavities that restore tooth interface. "
This disease is one of the leading causes of failure of dental restoration materials and affects approximately 100 million patients a year, at an estimated cost of more than $ 30 billion.
Historically, amalgam fillings made of metal alloys were used for dental restorations and had an antibacterial effect. But because of the bright color of the alloys, the potential toxicity of mercury, and the lack of tooth adhesion, new composite resin-based restoration materials have become the preferred choice of treatment. Unfortunately, the lack of antimicrobial property remained a major drawback for their use.
"We have developed an improved material that is not only aesthetically pleasing and rigid, but also inherently antibacterial because of the incorporation of antibacterial nano-bademblies," Schnaider said. "Composite resin fillings that exhibit bacterial inhibitory activity could significantly hinder the development of this widespread oral disease."
Scientists are the first to discover the potent antibacterial activity of the self-badembling Fmoc-pentafluoro-L-phenylalanine building block, which includes functional and structural subparts. Once the researchers established the antibacterial capabilities of this building block, they developed methods of incorporating nano-bademblages into dental composite restorations. Finally, they evaluated the antibacterial capabilities of composite restoration materials incorporating nanostructures, as well as their biocompatibility, mechanical strength and optical properties.
"This work is a good example of how biophysical characteristics at the nanoscale affect the development of an improved biomedical material on a much larger scale," Schnaider said.
"The minimal nature of the antibacterial building block, as well as its high purity, low cost, ease of integration into resin-based materials and its biocompatibility, make it easy to develop this approach for the development of new products. 39, an improved antibacterial resin composite available in clinical restorers, "says Dr. Adler-Abramovich.
Researchers are currently evaluating the antibacterial capabilities of several minimal self-badembling building blocks and developing methods for their incorporation into various biomedical materials, such as dressings and tissue scaffolds.
Source: American Friends of Tel Aviv University
Source link
