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A large-scale global study covering more than 100 academics from all over the world, discovered that anorexia nervosa was partly a metabolic disorder and not just psychiatric, as was previously known.
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The study was conducted by researchers from King's College London and the University of North Carolina at Chapel Hill, and the results were published in Genetic nature Monday.
What is anorexia nervosa?
Anorexia Nervosa is a very serious illness that can lead to life-threatening or life-threatening situations. The symptoms of the disease include extremely low body weight, a strong fear of gaining weight, and a distorted body image.
The disease affects 1-2 percent women, and 0.2-0.4% men in the world and has the highest death rate of all psychiatric illnesses.
What did the researchers find?
The team observed the data set of 16,992 case of anorexia nervosa 17 countries in Europe, North America and Australasia.
The main points discovered by the research are:
- Regardless of the genetic effects that influence the body mbad index (BMI), the genetic basis of the disease is closely related to metabolic, lipid (fat) and anthropometric (body measurements) characteristics.
- The genetic basis of anorexia nervosa is related to other psychiatric disorders such as obsessive compulsive disorder, depression, anxiety and schizophrenia.
- The genetic factors related to the disease also influence physical activity – which is why some people with anorexia nervosa are very active and athletic.
"The metabolic abnormalities seen in patients with anorexia nervosa are most often attributable to starvation, but our study shows that metabolic differences may also contribute to the development of the disease," said Dr. Gerome Breen, of the National Institute of Health Research (NIHR). the Institute of Psychiatry, Psychology and Neuroscience of King's College London.
A genome-wide badociation study identifies eight at-risk loci and involves metabo-psychiatric origins of anorexia nervosa (Watson et al.) Https://t.co/C3GX5EOARN pic.twitter.com/3hrZQeJaGW
– Nature Genetics (@NatureGenet) July 15, 2019
"In addition, our badyzes indicate that metabolic factors could play a role almost as important as purely psychiatric effects."
This discovery of research could help physicians and clinicians to develop better, and therefore appropriate, methods of treating the disease.
Our new @PGCgenetics the paper is out! 8 loci, metabolic and psychiatric correlations inspiring a new meta-psychosocial hypothesis of anorexia nervosa https://t.co/YHNfNou9FO
– (((Gerome Breen))) (@psychgenomics) July 15, 2019
For her part, Professor Janet Treasure, also from the Institute of Psychiatry, Psychology and Neuroscience at King's College London, said: "Over time, the incorporation of the University of London," said Dr. Anorexia nervosa as a whole has created uncertainties because of the combination of physical and psychiatric characteristics, and our results confirm this duality. "
The disorder may need to be considered a hybrid "metabo-psychiatric disorder". When treating anorexia nervosa, it will be important to take into account the metabolic and psychological factors.
Andrew Radford, managing director of Beat, UK's food-stress charity, said: "This is an innovative research that dramatically improves our understanding of the genetic origins of this serious illness. "
"Parents of people with eating disorders are incredible"@beatED Chief Executive Andrew Radford explains his new initiative to ensure health services use the parents of people with eating disorders https: //t.co/edK4vHsFF9 #VictoriaLIVE pic.twitter.com/uleb4yYhbK
– Victoria Derbyshire (@VictoriaLIVE) July 8, 2019
Radford concluded, "We strongly encourage researchers to review the results of this study and to think about how it can contribute to the development of new treatments to end the pain and suffering caused by by eating disorders. "
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