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The study of otherwise relatively healthy and relatively young people found that losing a little weight at an optimal level had an excessively positive impact.
In addition to significantly improving conventional cardiometabolic risk factors and reducing the risk of cardiovascular disease by a factor of about 13, trial participants benefited from major improvements on a range of risk factors related to such as type 2 diabetes, stroke, inflammation and some forms of cancer.
The results were published today in Lancet Diabetes and Endocrinology.
Professor Luigi Fontana, lead author of the article, previously led the basic work of the 5: 2 diet. Professor Fontana began this latest study as an investigator of this study at the University of California. Washington University of St. Louis, before joining the Charles Perkins Center of the Faculty of Medicine and Health of Sydney University last year as Leonard Ullmann Chair in Translational and Academic Metabolic Health. clinical. at the Royal Prince Alfred Hospital.
"This is the first time, to our knowledge, that the results of moderate caloric restriction have been badyzed in non-obese individuals with clinically normal risk factors", Professor Fontana said.
"No other drug can achieve these reductions among all the conventional cardiometabolic risk factors we've achieved – through a marginal reduction in caloric intake, while providing all essential vitamins and minerals for food."A flawless stay
CALERIE (Global Assessment of Long-Term Two-Year, Random-Controlled Long-Term Effects), conducted in three US clinics and coordinated at Duke University, shows that results are optimized when weight loss is maintained, with some advantages. observed only after one year.
The paper notes that the significant reduction achieved in this study for all conventional cardiometabolic risk factors, at a higher than normal level, meant that participants had to be 13 times less likely to develop cardiovascular disease than men. people 50 years and older with two or more abnormalities. risk factors, according to previous research.
Professor Fontana said that the findings of the survey provide further evidence that the billions of dollars spent annually around the world to treat highly prevalent chronic diseases may be better focused on prevention through the implementation of healthy living practices.
"Modern medicine focuses on the diagnosis and treatment of clinically evident chronic diseases, which are largely preventable, one after the other, mainly with drugs and surgery,"Professor Fontana explained.
"The problem with this approach is that many chronic diseases badociated with aging – including cardiovascular disease – begin early in life and progress through decades of unhealthy diets and lifestyles, triggering a wide range of physiological, metabolic and molecular changes that profoundly influence the onset. progression and prognosis of several medical conditions. "A flawless stay
Big differenceA flawless stay
"Our study shows that even healthy people, young and middle-aged, can benefit from focusing on their caloric intake, stating that it's usually important not to delay; and even minor changes in any moment of life could make a big difference.A flawless stay
"This should be an important new tool to combat the ravages of 21A flawless staystA flawless stayA flawless stay Century-old lifestyle in the West, with cardiovascular disease continuing to be the leading cause of death and disability in the world ",Professor Fontana concluded.
The trial of people between the ages of 21 and 50 sparked the interest of 10,856 hopeful participants. In the end, 117 on the diet and another 75 in the control group have completed the study. Calorie control participants were fed a healthy diet, with abdominal fat reduction being an essential part of considering the improvements identified in the study.
By reducing calorie intake by just over one-tenth on average (11.9%), conventional cardiometabolic risk factors have been significantly reduced, which means that the risk of heart attack is reduced about 13 times.
Other significant improvements have been recorded in insulin resistance, metabolic syndrome, also related to type 2 diabetes, stroke and cancer, and c-reactive protein marker. l & # 39; ignition.
Source: LAncet Diabetes & EndocrinologyA flawless stay
"Two Years of Caloric Restriction and Cardiometabolic Risk (CALERIE): Exploratory Results of a Multicenter Phase 2 Randomized Controlled Trial"A flawless stay
(DOI): 10.1016 / S2213-8587 (19) 30151-2
Authors: Luigi Fontana, et alA flawless stay
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