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Dr. Joseph Hyser Source: Baylor College of Medicine
Rotavirus, a virus that causes severe diarrhea and vomiting in children around the world, must invade the cells of the gastrointestinal tract and trigger an influx of calcium into the cells. How this surge occurs has not been clarified, but a report in the newspaper Scientific reports Published today shows in detail the dynamic changes in calcium following the invasion of rotavirus.
Researchers at Baylor College of Medicine and Indiana University have revealed that rotavirus induces hundreds of discrete and highly dynamic calcium peaks, which increase during the peak of infection. Calcium peaks can be attenuated by genetically destroying rotavirus protein NSP4, known to disrupt the balance of calcium in cells. The spikes come from the calcium released by the endoplasmic reticulum, a specialized structure within the cells, in the cytoplasm of the cell.
The results of the study open new avenues to better understand what the virus does to cause a disease.
Sugars and microbiome in bad milk influence neonatal rotavirus infection
Rotavirus Dysregulation Calcium Manifestations as dynamic signaling of calcium in the cytoplasm and endoplasmic reticulum, Scientific reports (2019). DOI: 10.1038 / s41598-019-46856-8
Quote:
The invasion of rotavirus cells triggers a cacophony of calcium signals (July 25, 2019)
recovered on July 25, 2019
from https://medicalxpress.com/news/2019-07-rotavirus-cell-invasion-triggers-cacophony.html
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