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Washington DC. [USA]July 27 (ANI): A recent study found that HIV-infected cells released vesicles containing a viral protein called Nef, further damaging cholesterol metabolism and causing inflammation in uninfected neighborhood cells. HIV infects only a limited repertoire of cells expressing HIV receptors. But HIV infection is also badociated with conditions involving the dysfunction of cells that can not be infected with HIV, such as hardening of the arteries, dementia, kidney failure and some heart problems. These HIV-badociated conditions persist even after the successful application of antiretroviral therapy. treatment in the absence of virus in the blood. Many of these conditions involve alterations in cholesterol metabolism. In the new study published in the journal PLOS Pathogens, researchers examined the mechanisms that may contribute to metabolic disorders badociated with HIV. The results showed that the HIV Nef protein is released from infected cells into vesicles that are then rapidly absorbed. by uninfected pbaders-by. white blood cells, altering the metabolism of cholesterol in these cells.This deficiency has resulted in the formation of excessive lipid rafts, as well as distinct lipid domains present in the outer leaf of the plasma membrane and the relocation of inflammatory receptors in rafts, triggering the # 39; ignition. The results demonstrate how a single viral molecule released from infected cells into the circulation can contribute to a range of pathogenic responses. "Our study highlights a common mechanism of various co-morbidities of HIV infection, which opens up the possibility of targeting this mechanism with the help of medications that affect cholesterol metabolism to treat multiple comorbidities in people living with HIV, "said one of the researchers in the study, Dmitry Sviridov. (ANI)
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