[ad_1]
The badually transmitted cancer, the "Canine Transmissible Venereal Tumor" (CTVT), is currently the subject of extensive research at the University of Cambridge. The researchers discovered that there may be another way to fight cancerous tumors.
TVCTs are estimated to have originated in Asia about 6,000 years ago and have since spread throughout the world. Due to the nature of cancer transfer between dogs, the cancer cells of dogs today have the same DNA as the original infected dog.
Researchers from the Communicable Cancer Group (TCG) at the University of Cambridge conducted research on TVRs in the hope that they could learn more about one of the cancer lineages. the most prolific of nature.
CTVs occur as bad tumors in domestic female and male dogs. The researchers tested 546 male and female dogs around the world. This large research group was intended to help scientists determine the origin and timing of the disease.
Adrian Baez-Ortega, PhD student, participates in the CTVT study. He said: "This tumor has spread to almost every continent, evolving as it spread … changes in its DNA tell the story of its origin and its origin. date, almost like a historical travel diary. "
What's up?
Using the data collected in this study, scientists created a phylogenetic tree. This tree allowed the researchers to create an original tree.
Originally from Asia, the disease would have been transferred to Europe because of the maritime activity of the time. Scientists have predicted that the disease then spread to the Americas about 500 years ago, when the first European settlers arrived on the continent by sea.
Researchers at the University of Cambridge found that all tumors found in North, Central and South America had the same point of origin from the same introductory event.
After being transferred to the Americas, it is thought that the disease was then transmitted to Africa and then to India.
Over the years, tumor DNA has mutated and unique signatures change according to various factors. The researchers identified five factors that modify the CTVT's DNA. The first four have already been identified in humans and have been linked to UV exposure. However, the fifth signature has not yet been identified in any other mammal. The signature called "Signature A" caused tumor mutations and damaged the DNA of the tumor a very long time ago. The signature is thought to be related to environmental factors that have not been identified since.
Dr. Elizabeth Murchison, head of the Communicable Cancer Group at the University of Cambridge, said, "It's really exciting. We have never seen anything similar to the model caused by this carcinogen … It looks like the tumor was exposed to something thousands of years ago that caused changes in its DNA during a some time, then disappeared. It's a mystery of what could be the carcinogen. Maybe it was something present in the environment where the cancer first appeared. "
Source link
