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Below are the summaries of the new articles that will be published in the next issue of Annals of Internal Medicine. Abstracts are not intended to replace full articles as a source of information. This information is subject to a strict embargo and, by taking possession of it, media representatives undertake to respect the terms of the embargo not only on their own behalf, but also on behalf of the organization they represent. .
1. Adherence to the low dose aspirin regimen has led to better pregnancy outcomes in women with previous miscarriages
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Close adherence to the low-dose aspirin regimen led to better pregnancy outcomes in women who had previously suffered miscarriages and were trying to conceive. The beneficial effect of aspirin was stronger if women started taking it before pregnancy and weaker if they started taking it after the 6th week of gestation. This protocol analysis of a randomized controlled trial is published in Annals of Internal Medicine.
In the Effects of Aspirin in Gestation and Reproduction (EAGeR) trial, researchers examined the effects of low-dose aspirin therapy initiated before conception on pregnancy loss and live birth in 1,227 women trying to become pregnant after 1 or 2 pregnancy losses. The trial found that women assigned to daily low-dose aspirin therapy before pregnancy did not have better pregnancy outcomes. However, many patients in the trial did not strictly adhere to the aspirin protocol, which was overlooked by the originally published intention-to-treat approach.
Researchers at Emory University and the National Institutes of Health used data from the EAGeR trial to conduct post hoc protocol analysis to determine whether taking aspirin almost daily would increase pregnancies or reduce loss. of pregnancy. The researchers compared the chances of pregnancy, miscarriage, and live birth that would have occurred with high levels of aspirin adherence versus placebo.
Per-protocol analysis showed that adherence to low-dose aspirin therapy for at least 5/7 days per week resulted in 8 more pregnancies, 6 fewer pregnancy losses, and ultimately 15 more live births per 100 women. participating in the trial. According to the authors, these results suggest that efforts to improve daily adherence to low-dose aspirin may improve the effectiveness of aspirin on reproductive outcomes in women trying to conceive.
Media Contacts: For an embargoed PDF, please contact Lauren Evans at [email protected]. Corresponding author Ashley I. Naimi, PhD, can be reached through Robert Bock at [email protected].
Also in this issue:
Emotions linked to the COVID-19 vaccine
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Graphic medicine
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