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DALLAS, March 11, 2021 – Having an ischemic stroke increases the risk of dementia, and that risk increases with the number and severity of strokes, according to preliminary research to be presented at the American Stroke International Stroke Conference 2021 Association. The virtual meeting will take place on March 17-19, 2021 and is a first global meeting for researchers and clinicians dedicated to stroke science and brain health.
Ischemic stroke is the most common type of stroke, accounting for 87% of all strokes. This happens when a blood vessel supplying the brain is blocked. Stroke is the leading preventable cause of disability in adults, and stroke severity is a primary determinant of poor functional outcome after stroke.
“Studies have shown that stroke is a strong predictor of dementia. What is not clear is how the severity of the stroke and having more than one stroke affects the risk of dementia, ”said study author Silvia Koton, Ph. D., MOccH, RN, FAHA, director of the Herczeg Institute on Aging at Tel Aviv University and director of the doctorate. program in the Department of Nursing, Sackler Faculty of Medicine, Tel Aviv University in Tel Aviv, Israel. “Our study uniquely characterizes the link between stroke and dementia and sets the stage for prevention strategies to reduce the risk of dementia after stroke.”
Researchers looked at the health information of nearly 15,800 baseline adults (aged 45-64) (enrolled 1987-89) from the Atherosclerosis Risk in Communities (ARIC) study, which is a study prospective in progress in four American communities (Forsyth County). , North Carolina; Jackson, Mississippi; the suburbs of Minneapolis, Minnesota; and Washington County, Maryland). The researchers used follow-up data from three decades of the ARIC database, which includes the enrollment period starting in 1987 and continuing through 2019 with data collected during in-person visits to several years of interval and follow-up phone calls made annually through 2012 and twice. every year until 2019.
Using all the information available in ARIC to study the link between stroke occurrence, stroke severity, and dementia, the researchers found:
- The risk of dementia in people who had at least one ischemic stroke was twice as high as in those without stroke.
- The risk of dementia increased with the severity and number of ischemic strokes.
- Adults who had a stroke were almost 80% more likely than those without stroke to have dementia.
- The risk of dementia increased to 8.5 times more likely in people who had three or more strokes during the study period, from 1987 to 2019.
- In adults who had a severe stroke, the risk of dementia was almost five times higher than in adults with a minor stroke.
“The association of stroke occurrence and stroke severity with the risk of dementia was surprisingly strong, and the continued increase in dementia risk after the first stroke and each subsequent stroke was a remarkable finding.” , Koton said.
“Our results underscore the importance of preventing stroke for preventing dementia and for maintaining high levels of physical and cognitive function and quality of life, especially at older ages,” Koton said. “Stroke is largely preventable. The treatment and control of high blood pressure, diabetes and obesity, as well as the adoption of a healthy lifestyle, which includes regular physical activity and a ban on smoking, are essential for prevention stroke and dementia.
The researchers only studied ischemic strokes. “It would be important to analyze the impact of other stroke subtypes on the risk of dementia,” Koton added. “Next, we plan to study the link between strokes and mild cognitive impairment, as well as between strokes and changes in cognitive performance over time. Future studies will also include information on brain imaging that will help assess the possible effects of vascular brain damage. smash. “
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Study co-authors are James Russell Pike, MBA; Michelle C. Johansen, MD, Ph.D .; David Knopman, MD; Kamakshi Lakshminarayan, MD, Ph.D .; Thomas Mosley, Jr., Ph.D .; Shalom Patole, MD, Sc.M .; Wayne D. Rosamond, Ph.D .; Andrea L. Schneider, MD, Ph.D .; A. Richey Sharrett, MD, Dr PH; Lisa M. Wruck, Ph.D .; Josef Coresh, MD, Ph.D .; and Rebecca F. Gottesman, MD, Ph.D. Author disclosures are listed in the abstract.
The National Institutes of Health funded this study.
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Statements and conclusions of studies presented at American Heart Association Scientific Meetings are solely those of the study authors and do not necessarily reflect the policy or position of the Association. The Association makes no representations or warranties as to their accuracy or reliability. The Association mainly receives funds from individuals; foundations and businesses (including pharmaceutical, device and other manufacturers) also donate and fund specific Association programs and events. The Association has strict policies to prevent these relationships from influencing scientific content. The revenues of pharmaceutical and biotechnology companies, device manufacturers and health insurers are available here, and the Association’s aggregate financial information is available here.
The American Stroke Association’s International Stroke Conference (ISC) is the world’s premier meeting devoted to the science and treatment of cerebrovascular disease. ISC 2021 will be held virtually from March 17-19, 2021. The 3-day conference will feature over 1,200 compelling presentations in 21 categories that focus on basic, clinical and translational sciences as they evolve into a better understanding of the pathophysiology of stroke with the aim of developing more effective therapies. Participate in the International Stroke Conference on social media via # ISC21.
About the American Stroke Association
The American Stroke Association is dedicated to saving people from stroke – the second leading cause of death in the world and one of the leading causes of severe disability. We team up with millions of volunteers to fund innovative research, fight for stronger public health policies, and provide vital tools and information to prevent and treat stroke. The Dallas-based association was officially launched in 1998 as a division of the American Heart Association. To learn more or to get involved, call 1-888-4STROKE or visit stroke.org. Follow us on Facebook, Twitter.
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