Obesity Increases Risk Of Type 2 Diabetes In Women With PCOS, Study Finds



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Losing weight can help women with PCOS effectively control symptoms. It can also help prevent complications related to this condition.

Obesity Increases Risk Of Type 2 Diabetes In Women With PCOS, Study Finds

PCOS affects women of childbearing age

A study conducted by the Endocrine Society addressed the importance of weight control in women with polycystic ovary syndrome (PCOS) and pointed out that symptoms of sleep during menopause may reduce susceptibility to weight gain.

“Our results suggest that not only estrogen withdrawal, but also trouble sleeping during menopause may contribute to changes in a woman’s body that could predispose women in their 40s to weight gain,” said Principal investigator Leilah Grant, Ph.D., of Brigham and Women’s Hospital in Boston, Mass. “Helping women sleep better during menopause can therefore reduce a woman’s chances of gaining weight, which in turn will lower her risk of diabetes and other related diseases.”

Obesity rates increase in women around the age of menopause. Menopause-related weight gain is often thought to be caused by the withdrawal of the female hormone estrogen. However, estrogen is unlikely to be the only contributing factor, as all women stop producing estrogen during menopause when only about half of women gain weight, Grant said. Another common symptom, also affecting about half of women during menopause, is disturbed sleep, which has been independently linked to changes in metabolism that may increase the risk of weight gain.

To better understand the role of sleep disturbances and hormonal changes in postmenopausal weight gain, researchers studied 21 healthy premenopausal women. They used an experimental model simulating the sleep disturbances experienced during menopause to examine the effects of poor sleep on the body’s use of fat.

Participants had two nights of uninterrupted sleep followed by three nights of interrupted sleep, where they were woken up by an alarm every 15 minutes for 2 minutes each time. The researchers then re-studied a subset of nine participants in the same sleep interruption protocol after receiving a drug called leuprolide, which temporarily suppressed estrogen to levels similar to menopause.

Compared to a normal night’s sleep, after three nights of disturbed sleep, there was a significant reduction in the rate of fat utilization by the female body. A similar reduction in fat use was also seen when estrogen was suppressed, even during normal sleep. The combination of low estrogen and sleep disturbances also reduced fat utilization, but the effect was no greater than either exposure alone.

“In addition to estrogen withdrawal, sleep disturbances decrease fat utilization,” Grant said. “It may increase the likelihood of fat storage and subsequent weight gain during menopause.”

(This story was not edited by NDTV staff and is auto-generated from a syndicated feed.)

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