Risk Score with 6 Routine Laboratory Tests Accurately Predicts Kidney Failure

Researchers developed a new risk equation, based on six patient parameters that are routinely available, which has improved performance in estimating the risk that a patient with chronic kidney disease (CKD) progresses to chronic kidney disease (CRD). end-stage kidney disease (ESKD) requiring kidney replacement therapy (KRT).

A new risk equation for the rapid identification of patients with chronic renal failure (CRF) at risk of progressing to renal failure requiring renal replacement therapy has been developed in 4,915 patients with stage 1 CRF to 5 with and without albuminuria, German chronic kidney disease (GCKD) study. It includes six laboratory tests: serum creatinine, albumin, cystatin C and urea, in addition to hemoglobin and urine albumin / creatinine ratio. The newly derived 6-variable risk score (Z6) achieved high predictive performance and good calibration both in a resampling approach in the GCKD study and in three independent validation cohorts that included a total of 3,063 patients with CKD. The implementation of this risk equation in clinical practice holds promise for improving patient care.

###

American Journal of Kidney Disease (AJKD)

ARTICLE TITLE: A Predictive Model of the Progression of CKD to Renal Failure Based on Routine Laboratory Tests

AUTHORS: Helena U. Zacharias, PhD, Michael Altenbuchinger, PhD, Ulla T. Schultheiss, MD, Johannes Raffler, PhD, Fruzsina Kotsis, MD, Sahar Ghasemi, MSc, Ibrahim Ali, MBBS, MSc, Barbara Kollerits, PhD, MPH, Marie Metzger, PhD, Inga Steinbrenner, MSc, Peggy Sekula, PhD, Ziad A. Massy, ​​MD, Christian Combe, MD, PhD, Philip A. Kalra, MD, Florian Kronenberg, MD, Bénédicte Stengel, MD, PhD, Kai- Uwe Eckardt, MD, Anna Köttgen, MD, MPH, Matthias Schmid, PhD, Wolfram Gronwald, PhD, Peter J. Oefner, MD, PhD, on behalf of GCKD researchers

DOI: https: //do I.org /ten.1053 /j.ajkd.2021.05.018