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LOS ANGELES, Jan. 24 (Xinhua) – Scientists have developed a new drug that could potentially stop the growth of cancer cells by delaying their biological clock.
The findings of scientists at the Michelson Center for Michelson Convergent Biosciences of the University of Southern California (USC) and the Institute of Transformative Biomolecules of Nagoya University in Japan have made it possible to make Advancing a burgeoning field of research: transforming the body's circadian rhythm against cancer.
The study was published Wednesday in the journal Science Advances.
Scientists conducted research on human kidney cancer cells and acute myeloid leukemia in mice.
As disrupting sleep and other elements of the circadian rhythm of the human can harm the health, it is the same for the circadian clock of the cells themselves. According to research, by disrupting the circadian clock of cancer cells, these could potentially be injured or killed.
Scientists have discovered that a molecule called GO289 targets an enzyme that controls the circadian rhythm of the cell. This drug-protein interaction then disrupts the functions of four other proteins that are important for cell growth and survival.
According to research, the GO289 can block the circadian clockwork of the cell, thus slowing down its cycles and having little impact on healthy cells.
"In some cancers, the disease takes up the circadian clock mechanism and uses it for the nasty purpose of developing," said Steve Kay, director of convergent biosciences at the USC Michelson Center. "With GO289, we can interfere with these processes and prevent cancer from developing."
Kay expressed optimism about the results. "It could become an effective new weapon that kills cancer," he said. Enditem
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