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David T. Gilbertson
There may be a relationship between seasonal fluctuations in influenza-like illness and seasonal variations in mortality in patients with TIR, which can contribute to more than 1,000 deaths per year, according to a study published in the Journal of the American Society of Nephrology.
"In general, during the flu /[influenza-like illness] Influenza-like illness (ILI) seasons when influenza and influenza-like illness peaked early, more deaths occurred early, and when the peak of the illness was late, the peak of deaths was also later, " David T. Gilbertson, PhD, Co-Director of the Chronic Disease Research Group of the Hennepin Healthcare Research Institute and Associate Professor of Medicine at the University of Minnesota, Healio Nephrology. "Similarly, the years when flu and influenza-like illness were particularly severe were generally years when the number of deaths was also higher than expected. Although ILI may not be the direct cause of death in patients with end-stage renal disease, it may also contribute to other causes of death; for example, patients with ILI may have a state of acute inflammation, making them vulnerable to other infections or cardiovascular events. "
To examine the relationship between seasonality of influenza activity and seasonal patterns of mortality in IRS patients, researchers used data from the US Influenza-Related Illness Surveillance Network, which CDC monitors influenza and related activity, and CMS, whereby the researchers obtained the total number of deaths among patients with SRI between 2000 and 2013. The number of deaths was examined by quarter, fourth quarter 2000 in the fourth quarter of 2012, quarters four and one corresponding to each influenza season.
Once researchers took into account the general upward trend in deaths due to the increase in the prevalence of the LAT population, they calculated the quarterly relative mortality as the average number of deaths in the third quarter (summer). ).
The researchers found that an increase of about 1% in the quarterly frequency of influenza-like illness was badociated with a 1.5% increase in relative mortality in the fourth quarter and a 2% increase in relative mortality in the first quarter.
There may be a relationship between seasonal fluctuations in influenza-like illness and seasonal variations in mortality in patients with TIR.
Source: Adobe Stock
In addition, the researchers concluded that an average of 1,100 deaths per year in patients with SRI could be due to flu-like illness.
"The findings of our study confirm the importance of close surveillance, prevention and treatment to reduce deaths badociated with influenza and influenza-like illness," Gilbertson said. "Further research is needed to find ways to improve influenza vaccination rates in patients with SRI and to find optimal vaccination strategies for these patients. For example, should all patients with ultra-peripheral renal failure receive high-dose vaccines or adjuvanted vaccines? Or, since there are signs of decreased immunity after vaccination in patients with end-stage renal disease, a new vaccination during the flu season offers it benefits? "- by Melissa J. Webb
Disclosures: Gilbertson does not report any relevant financial information. Please consult the study for the relevant financial information of all other authors.
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