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Fish oil does not seem to improve asthma control in obese youth: study & nbsp | & nbspPhoto Credit: & nbspThinkstock
Washington DC: A new study now reveals that fish oil does not appear to improve asthma control in overweight or obese adolescents and young adults. The study was published online in the Annals of the American Thoracic Society.
In "Fish Oil Supplementation in Obese or Overweight Patients with Uncontrolled Asthma: a Randomized Trial," Jason E Lang and his co-authors report that four grams of fish oil per day during six months did not improve asthma control as measured by standard asthma. control questionnaire, respiratory tests, urgent care visits and severe exacerbations of asthma.
"We do not know why controlling asthma in obese patients is harder, but there is more and more evidence that obesity causes systemic inflammation," said lead author of the study. Study, Dr Lang, adding: "Because omega-3 fatty acids in fish oil have anti-inflammatory properties, we wanted to test whether fish oil would have any therapeutic benefits for these patients. "
Patients in the study were all diagnosed with asthma by a physician, but their asthma control was poor, despite the daily use of an inhaled corticosteroid to control their condition. About half of the participants were African American. Of three participants badigned to take fish oil for 25 weeks, one was badigned the placebo for soybean oil.
The researchers also examined whether a variant of the ALOX5 gene affected the results of the study. It is known that mutations in the gene may reduce responses to anti-leukotriene drugs. In the study, the variant ALOX5 appeared to be related to leukotriene production but not to the effectiveness of fish oil in controlling asthma.
According to the authors, the negative conclusions of the study might not be the last word on fish oil and asthma. They recognized that larger doses of fish oil over a longer period can produce a different result.
However, Dr. Lang concluded that, according to the current study, "clinicians do not have enough evidence to suggest that uncontrolled asthmatic patients take daily fish oil supplements to help with their asthma."
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