Arsenal will be deprived of Sokratis Papastathopoulos for a month, which will bring an extra blow to their hopes of placing in the top four.
Laurent Koscielny's situation is better, but the Gunners continue to monitor their captain.
Unai Emery players were eliminated from the FA Cup on Friday night. Manchester United has qualified for the fifth round with a 3-1 win at the Emirates and the Spaniard will be deprived of the defensive pair for the Premier League match with Cardiff City on Tuesday.
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The Greek international fell awkwardly on the ankle against United after beating the ball with Jesse Lingard and was replaced by Shkodran Mustafi after 21 minutes.
As the skipper of the Gunners took Romelu Lukaku to the head to put him out of action.
Arsenal has since provided an update and bad news regarding Sokratis and his left ankle. The 30-year-old "should resume full training by the end of February".
The news from Koscielny reveals that Gunners supporters have better news: "bruising and swelling of soft tissues in the face and jaw", and although the problem is not serious, the back center will be " examined daily ".
Sokratis goes after suffering an injury against United (PA)
Emery's initial view of the injuries was optimistic and stated, "I do not think they were serious for Sokratis. [his ankle]. Maybe Laurent Koscielny goes to the hospital for [badyse] what an injury he has. Maybe it's broken [his cheek or jaw] but I hope not. "
Henrikh Mkhitaryan could be soon back from a fractured metatarsal on his right foot and the player is being "reintegrated into a full training".
The problem of Hector Bellerin's left knee is still being evaluated before the operation. Rob Holding is rehabilitated after a successful left knee surgery.
Danny Welbeck is still missing with a right ankle injury.
Keep up-to-date with the latest transfer news, rumors and offers throughout the January window