An & # 39; cell of origin & # 39; unauthorized can trigger all types of cancer, according to research



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According to new research, all cancers could be caused by a rare dishonest stem cell that has learned to deceive death.

Scientists believe that the discovery of the "cell of origin" could constitute a turning point in the fight against the disease.

Lead Professor Michael Lisanti, director of translational medicine research at the University of Salford, said, "If, as we believe, we have found the beginning of the road, we may have to press the button reset to find out how we treat cancer with drugs. "


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The team isolated the most energetic cells in a series of cultured cell lines derived from bad tumors.

The most dynamic cancer stem cells, representing only 0.2% of the total population, had special characteristics and a level of energy well above average.

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These cells have also shown strong signs of senescence – an aging-related process that causes cells to gel at the end of life and prevent them from multiplying.

"They showed distinctive signs of senescence but are no longer, they came out of senescence," said Professor Lisanti.

Scientists believe that "mother" cancer cells can use antioxidants and energy from mitochondria – cellular powerhouses – to redirect their fate.

Professor Lisanti said, "Scientists talk about cancer caused by the regeneration of dying cells, called zombie cells. We now see that it's more dramatic than that. In fact, it could be described more accurately as a break in prison. In other words, this original cell detaches itself and unleashes itself, multiplying the malignant cells and creating a tumor. "

He added, "It looks like finding the needle in a haystack, which gives us a new window on cancer and how we could stop it."

There is growing evidence that the deadly spread of cancer, called metastasis, is caused by mitochondria-fueled cancer stem cells, scientists said.


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Yet most chemotherapies targeted "en mbade" cancer cells and some treatments even allowed cancer stem cells to proliferate further.

The research was published in the journal Frontiers in Oncology.

Press Association

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