[ad_1]
An anti-cancer drug that uses an unprecedented "Trojan horse" approach to destroy tumors from within has shown promising results for six different forms of the disease.
British researchers have welcomed the results of the first drug tests, known as tisotumab vedotin (TV), after stopping or narrowing tumors in patients who had no option.
The treatment combines an anticancer chemotherapy agent with an antibody, a biological molecule that binds to markers on the surface of cancer cells and drives the drug inside.
Join Independent spirits
For exclusive items, events and an ad-free reading for only
£ 5.99
$ 6.99
$ 9.99
a month
Get the best of L & # 39; Independent
With an Independent Minds subscription for only
£ 5.99
$ 6.99
$ 9.99
a month
Get the best of L & # 39; Independent
Without ads – for just
£ 5.99
$ 6.99
$ 9.99
a month
All patients did not respond to treatment, but its effects lasted on average 5.7 months and up to 9.5 months in some people, in tests involving bladder cancer, ovarian lungs and cervix that no longer responded to conventional drugs.
"What is really exciting about this treatment, is that its mechanism of action is completely new.It acts as a Trojan horse to infiltrate cancerous cells and kill them. inside, "said Professor Johann de Bono, of the Cancer Institute, looking.
1/13
Stop smoking. This notoriously difficult habit to break sees the accumulation of tar in the lungs and the alteration of DNA and causes 15,558 cancer deaths
2/13
Avoiding the sun and melanoma badociated with overexposure to harmful UV rays, could help conscientious shade-goers to dodge the fact of being one of the 7,220 people who die from it
3/13
According to one study, a diet low in red meat can help prevent bowel cancer – 30 grams a day are recommended for men and 25 a day for women.
4/13
Fiber-rich foods can contribute to healthy intestines. Processed foods in developed countries seem to cause higher rates of colon cancer than those in European countries such as Africa, where beans and impulses are high
5/13
Two servings of fruit and three servings of vegetables a day were given as a magic number for good nutrition as part of the research. Overall, diet causes only slightly fewer cancer deaths than sun exposure in Australia (7,000 per year)
6/13
Overweight and obesity, related to poor diet and lack of physical exercise, cause 3,917 cancer deaths per year
Getty
7/13
Dying from cancer caused by infection is also an important factor, linked to 3,421 cancer deaths each year. Infections such as human papillomavirus – which can cause cervical cancer in women – and hepatitis – can be prevented by vaccination and regular checkups
8/13
Reduced consumption may reduce the risk of alcohol-related cancers, such as liver cancer, bowel cancer, bad cancer and oral cancer, resulting in 3,208 deaths per year.
2014 Getty Images
9/13
Sitting without moving your heart – less than an hour of exercise a day – leads to about 1,800 people to have lower immune functions and higher hormone levels, among other factors, which cause cancer.
2011 Getty Images
10/13
Hormone replacement therapy, which is used to relieve menopausal symptoms in women, caused 539 cancer deaths (mostly bad cancer) in Australia last year. However, he prevented 52 cases of colorectal cancer
2003 Getty Images
11/13
Oddly enough, badfeeding is insufficient in the top 10. Breastfeeding for 12 months could prevent 235 cancer cases a year, according to research.
AFP / Getty Images
12/13
Oral contraceptives, like the pill, caused about 105 bad cancers and 52 cervical cancers – but they also prevented about 1,440 ovarian and uterine cancers ( uterus) last year.
2006 Getty Images
13/13
Taking aspirin has also avoided 232 cases in colorectal and oesophageal cancer research in Queensland – but as it can also cause strokes, it is not yet recommended as a formal treatment for the risk of cancer.
1/13
Stop smoking. This notoriously difficult habit to break sees the accumulation of tar in the lungs and the alteration of DNA and causes 15,558 cancer deaths
2/13
Avoiding the sun and melanoma badociated with overexposure to harmful UV rays, could help conscientious shade-goers to dodge the fact of being one of the 7,220 people who die from it
3/13
According to one study, a diet low in red meat can help prevent bowel cancer – 30 grams a day are recommended for men and 25 a day for women.
4/13
Fiber-rich foods can contribute to healthy intestines. Processed foods in developed countries seem to cause higher rates of colon cancer than those in European countries such as Africa, where beans and impulses are high
5/13
Two servings of fruit and three servings of vegetables a day were given as a magic number for good nutrition as part of the research. Overall, diet causes only slightly fewer cancer deaths than sun exposure in Australia (7,000 per year)
6/13
Overweight and obesity, related to poor diet and lack of physical exercise, cause 3,917 cancer deaths per year
Getty
7/13
Dying from cancer caused by infection is also an important factor, linked to 3,421 cancer deaths each year. Infections such as human papillomavirus – which can cause cervical cancer in women – and hepatitis – can be prevented by vaccination and regular checkups
8/13
Reduced consumption may reduce the risk of alcohol-related cancers, such as liver cancer, bowel cancer, bad cancer and oral cancer, resulting in 3,208 deaths per year.
2014 Getty Images
9/13
Sitting without moving your heart – less than an hour of exercise a day – leads to about 1,800 people to have lower immune functions and higher hormone levels, among other factors, which cause cancer.
2011 Getty Images
10/13
Hormone replacement therapy, which is used to relieve menopausal symptoms in women, caused 539 cancer deaths (mostly bad cancer) in Australia last year. However, he prevented 52 cases of colorectal cancer
2003 Getty Images
11/13
Oddly enough, badfeeding is insufficient in the top 10. Breastfeeding for 12 months could prevent 235 cancer cases a year, according to research.
AFP / Getty Images
12/13
Oral contraceptives, like the pill, caused about 105 bad cancers and 52 cervical cancers – but they also prevented about 1,440 ovarian and uterine cancers ( uterus) last year.
2006 Getty Images
13/13
Taking aspirin has also avoided 232 cases in colorectal and oesophageal cancer research in Queensland – but since it can also cause strokes, it has not yet been recommended as a formal treatment for cancer. cancer risk.
"Our first study showed that it could potentially treat a large number of cancer types, especially those with very low survival rates."
New drugs are being tested in patients with advanced cancers because they may be as toxic as the disease.
However, the Bono professor said that the television had "manageable side effects" and that the drug was now moving to a larger, stage two clinical phase, using the drug as a second-line treatment for cervical cancer.
The first-phase trial involved nearly 150 patients with different types of drug-resistant cancer and its findings were published in the journal Oncology Lancet.
Patients with bladder cancer or servicecal cancer were the most likely to respond to treatment, which worked respectively in 27% and 26.5% of cases.
In esophageal cancer and non-small cell lung cancer, 13% of patients reported a benefit, but there was no response to prostate cancer.
Support freethinking journalism and subscribe to Independent Minds
However, the promising results mean that ICR's Dr. de Bono team and the Royal Marsden Hospital will also test it in bowel and pancreatic cancer.
Pancreatic cancer has one of the worst survival rates of all major forms of the disease and experts hope that television could help address the lack of treatment.
"We are in desperate need of innovative therapies like this one that can fight cancer in a novel way and remain effective even against tumors that have become resistant to conventional treatments," said Professor Paul Workman, chief executive officer of the group. ; ICR.
Source link
