Recurrent risk of wheezing associated with prenatal exposure to acid inhibitors

February 23, 2019

The researchers badyzed the risk of occurrence of recurrent wheezing in a prospective cohort study conducted in infants in whom severe bronchiolitis was diagnosed.

SAN FRANCISCO – Prenatal exposure to acid-blocking drugs in infants with a history of severe bronchiolitis could increase the risk of occurrence of recurrent wheeze before the age of 3 years, according to a study presented at the annual meeting of the American Academy of Allergy Against Asthma and Immunology, held Feb. 22-25, 2019, in San Francisco, California.

The researchers badyzed the risk of occurrence of recurrent wheezing in a prospective cohort study conducted in infants with severe bronchiolitis. Data were collected on hospitalized infants for bronchiolitis using a parenting report to determine demographics, use of pregnancy medications, gestational variables, and methods of diagnosis. # 39; s birth. These infants were then followed up at the age of 3 to monitor the appearance of recurrent wheezing and asthma.

Of the 900 infants included in the data badysis, 144 were exposed to acid-suppressing drug before birth and 39% of these infants developed recurrent wheezing at the age of 3 years. Of the 756 infants not exposed to acid-suppressing drug before birth, 31% had recurrent wheezing (unadjusted risk ratio, 1.39, 95% CI, 1.03 to 1.85 ). After adjustment for demographic variables, Cox-proportional multivariate risk models indicated an adjusted risk ratio of 1.40 (95% CI, 1.02-1.91) for children exposed to suppressive drugs of acid who were suffering from wheezing before birth.

The researchers concluded, "In this high-risk cohort of American children with a history of severe bronchiolitis, prenatal exposure to [acid suppressant medication] further increases the risk of developing recurrent 3-year wheezing. "

Reference

Robinson LB, Chen Arroyo AJ, MAS Dantas, Espinola JA, Sullivan AF, Camargo CA Jr. Prenatal exposure to antacid drugs and risk of recurrent wheezing at 3 years of age in children with a history of severe bronchiolitis. Presented at the annual meeting of the American Academy of Allergy, Asthma and Immunology, 2019; February 22-25, 2019; San Francisco, CA. Summary 238.