New evidence on the role of the gut microbiome in improving human health



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Miami, Florida (March 23, 2019) – The intestinal microbiome is one of the most dynamic scientific fields. Twenty-three new abstracts presenting the most advanced advances in gut microbiome research will be presented at the eighth annual Global Microbiota for Health Summit to be held on March 23-24, 2019 in Miami. , in Florida. This leading meeting on the gut microbiota is sponsored by the American Association of Gastroenterology (AGA) and the European Society of Neurogastroenterology and Motility (ESNM). It will provide health professionals with the most up-to-date data on the interaction between diet, nutrition and gut microbiome.

Below you will find a summary of three of the most remarkable abstracts that will be presented at the 2019 World Summit on Gut Microbiota. Please contact [email protected] to speak to one of the researchers listed here or to receive the book complete abstracts. The award to the 2019 Global Summit on the Gut Microbiota for Health, organized by the American Association of Gastroenterology (AGA) and the European Society of Neurogastroenterology and Motility (ESNM), is required in all areas.

A new way to control inflammation in the intestine

Title of the study: Regulation of the expression of P-glycoprotein on the intestinal epithelium by the microbiome for maintenance of homeostasis

  • Sage Foley et al. University of Mbadachusetts Medical School

Significance: The authors identified a novel pathway controlling inflammation in the gut that is dependent on P-glycoprotein, which prevents neutrophils (a type of immune cell) from infiltrating the intestines and causing inflammation. Neutrophil infiltration is a key feature of inflammatory bowel disease. In mice, antibiotics have been shown to reduce the presence of butyrate-producing Clostridium bacteria – a molecule that has previously been shown to induce P-gene expression. glycoprotein. The authors conclude that these bacteria play a role in controlling the balance between health and disease by regulating the function of P-glycoprotein.

The diet can help prevent It's hard infection in high-risk populations

Title of the study: Diet module Clostridioides difficult pathogenesis by the metabolism of bile acid from the host and microbes

  • Keith Hazleton et al. University of Colorado, Anschutz Medical Campus and Colorado Children's Hospital

Significance: The authors studied the impact of diet on susceptibility to Clostridioides difficult infection, a life-threatening infection affecting more than 500,000 people in the United States each year. In mice, they showed that mice fed a "western" diet (high fat / low fiber)It's hard environment in the intestine. Authors conclude that a diet-based intervention could have prevention potential It's hard infection in people at high risk.

Prebiotics can prevent the effects of radiation therapy

Title of the study: Reduced oral nutrition contributes to the gastrointestinal toxicity of total body irradiation through changes in the intestinal microbiome.

  • Robert R. Jenq et al. University of Texas MD Anderson Cancer Center

Significance: The authors studied the impact of radiation on the intestinal microbiome and the intestinal barrier with the help of a mouse model. In mice exposed to total body irradiation, changes in the intestinal microbiome were badociated with thinning of the intestinal mucus and altered intestinal barrier. The administration of a prebiotic supplement has prevented these effects, indicating the potential for nutritional intervention in patients treated for hematological cancer.

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About the World Summit on Gut Microbiota 2019

The Eighth Annual Global Summit on Gut Microbiota for Health will be held on March 23-24, 2019, in Miami, Florida, USA, and will present the latest advances in the interaction between food, nutrition and the microbiome. intestinal. This preeminent meeting on the gut microbiota is sponsored by the American Association of Gastroenterology (AGA) and the European Society of Neurogastroenterology and Motility (ESNM) and approved by the American Society of Neurogastroenterology and Motility (ANMS) and the Society European gastroenterology, hepatology and pediatrics. Nutrition (ESPGHAN), with support from Danone (Founding Supporter of GMFH), Sanofi (Permanent Supporter), Bio-K + International Inc., Rebiotix Inc., part of the Ferring Pharmaceuticals Group, and Seres Therapeutics ( 2019 Supporters). The Scientific Committee is co-chaired by Gail Hecht, MD, MS, AGAF, (Loyola University Medical Center, Chicago, Illinois, USA) and Francisco Guarner, MD, Ph.D. (Vall d 'University Hospital). Hebron, Barcelona, ​​Spain). Learn more about https: //www.microbiota for health.com /in /intestinal summit-microbiota-health-world-2019 /.

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About the AGA Institute

The American Gastroenterological Association is the trusted voice of the GI community. Founded in 1897, the AGA now has more than 16,000 members worldwide, involved in all aspects of the science, practice and progress of gastroenterology. The AGA Institute administers the organization's practice, research and education programs. http: // www.gastro.org.

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About the gut microbiota and health section of the NMHS

ESNM represents the European Society of Neurogastroenterology and Motility, member of United European Gastroenterology (UEG). ESNM's mission is to defend the interests of all European professionals involved in the study of the neurobiology and pathophysiology of gastrointestinal function. The Intestinal Microbiota and Health section was created to better recognize the links between the gut microbiota and human health, to highlight the role of food and nutrition, to disseminate knowledge and to stimulate awareness. interest in the subject. The Microbiota Intestinal and Health Section is open to professionals, researchers and practitioners in all areas related to gut microbiota and health. http: // www.NMES.EU.

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