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Washington DC, March 23: According to a recent study, researchers have discovered a drug that can successfully treat life-threatening liver diseases, such as cirrhosis.
The study was published in the Journal of Gastroenterology. Although there are drugs to treat some forms of liver diseases, such as hepatitis C and autoimmune hepatitis. But for conditions such as portal hypertension, where there is an increase in pressure in the portal vein that carries blood from the abdominal organs to the liver. This is badociated with cirrhosis and other chronic liver diseases. Lift weights for a healthy liver! Bodybuilding can help reduce fatty liver disease.
According to the researchers, a drug called Sivelestat could actually reduce portal hypertension, thereby improving symptoms and outcomes for these patients. The results of the study were obtained from murine models but have since been confirmed in liver samples taken from humans.
"It was an exciting confirmation of our results and applicability to human disease.Sivelestat has been safely used in humans with acute lung injury and bronchial dysplasia liver disease," said co-author Vijay Shah .
The study showed that fibrin deposits, microvascular blood clots, contributed to portal hypertension and that inflammatory cells known as neutrophils contributed to fibrin formation. By inhibiting neutrophil function with Sivelestat, they were able to reduce portal hypertension.
The results were verified in two different models of chronic liver disease. "Neutrophils have not yet been identified as important factors in portal hypertension," said co-author, Moira Hilscher. Due to the increasing prevalence of advanced liver disease due to alcohol and obesity, this study paves the way for the development of new drugs and the reuse of existing compounds to target drugs. 39, inflammation of the liver.
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