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For patients with Parkinson's disease (PD), the characteristics of sleep behavior disorder with rapid eye movements are clinical markers of a faster cognitive decline and possibly motor progression, according to the results published in Parkinsonism and related disorders.
RBD is characterized by a dream interpretation and has already been badociated with an increased incidence of neurodegenerative disorders, including PD.
The study included participants with PD (n = 776). Researchers screened participants for RBD. Motor characteristics were badessed using the Unified Parkinson's Assessment Scale (UPDRS Parts I, III and IV) and the Hoehn and Yahr clbadification. Participants also took the Mini Mental State Examination (MMSE).
The researchers compared participants with and without probably RBD (pRBD) who had at least one follow-up (60%) to estimate risk ratios for progression events, defined as UPDRS-III ≥35 and MMSE ≤24.
Initially, 21% of participants had a DRbP. Participants with DRPb tended to be male and had more diagnoses of myocardial infarction, anxiety, and depression self-reported before the start of the study.
In Cox regression models fitted to participants with a postural instability phenotype and gait dysfunction, those with pRBD progressed more rapidly to an UPDRS-III ≥ 35 (HR 1.92, 95% IC, 1.12-3.27) compared to those without pRBD.
Compared with participants without pRBD, all those with PRBD increased twice as fast to an MMSE score ≤ 24 (HR 2.04, 95% CI 1.13-3.69).
"RBD characteristics can be a simple and useful way to screen for treatment trials and, in clinical practice, to identify patients at risk for faster progression, likely to benefit from pharmacologic treatment." therapeutic regimens) and non pharmacological (including physical activity and prevention of falls). ) interventions, "wrote the researchers.
Reference
Mad AD, Paul KC, Bronstein JM et al. Clinical Progression of Parkinson's Disease with Characteristics of REM Behavior Disorder: A Longitudinal Population Study [published online January 29, 2019]. Parkinsonism Disorder. doi: 10.1016 / j.parkreldis.2019.01.018
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