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A Scottish woman felt no pain or feared several surgeries later due to an unknown gene mutation until then. The researchers said that the FAAH-OUT gene was responsible for regulating pain, mood and memory signals. ( University College London )
Doctors discover a new genetic mutation in a woman that makes her nearly incapable of feeling pain and stress, even after several surgeries.
Jo Cameron, 71, said that she had always been a cheerful person, but she did not realize it had anything to do with her genes.
The researchers believe that the study of this genetic mutation will eventually lead to new treatments for chronic pain.
Almost invincible
Cameron, a retired teacher from Inverness, Scotland, was abandoned once in her car after being hit on the road. She suffered only bruising and did not notice her until after the incident.
She has always been optimistic and her depression test score has returned to zero. When she underwent hip arthroplasty, she managed to relieve the pain with only two paracetamol the next day.
The doctors also performed double manual surgery because of his osteoarthritis, a procedure that was supposed to be extremely painful. Cameron had almost no pain, prompting his specialists to undergo genetic testing.
"It's what's called the happy gene or forgetful gene, I've been bothering people by being happy and forgetful all my life, I have an excuse now," he said. she said in an interview.
Double mutation
A team of researchers from University College London led by Dr. James Cox studied Cameron's case. They discovered that her healing improvement and her terrifying sense of fear and anxiety were due to a genetic mutation previously unknown.
The UCL team, in collaboration with pain geneticists at the University of Oxford, performed genetic badyzes. Two notable mutations appeared, responsible for the signal of pain, mood and memory.
The gene, later called FAAH-OUT, was only briefly annotated in the earlier literature. Scientists initially thought that it was an undesirable gene without function.
About one in two patients experience moderate to severe pain after surgery, even with advanced pain relief.
"The findings suggest a new badgesic discovery that could potentially offer postoperative pain relief and also accelerate wound healing, which we hope could help the 330 million patients who undergo surgery every year in the area. world, "said Dr. Devjit Srivastava, consultant in anesthesia and pain medicine and co-author of the article.
The details of Cameron's case were published in the British Journal of Anesthesia.
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