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Mbadachusetts General Hospital and Harvard Medical School, Boston, Mbadachusetts (C.M.D., A.L.C., K.A.F.)
University of Cape Town, Cape Town, South Africa (L.B., L.M., R.W.)
Mbadachusetts General Hospital, Boston, Mbadachusetts (M.E.S.)
Harvard Medical School and Brigham and Women's Hospital, Boston, Mbadachusetts (P.E.S.)
Columbia University, New York, New York (E.J.A.)
Mbadachusetts General Hospital, Harvard Medical School and Brigham and Women's Hospital, Boston, Mbadachusetts (R.P.W.)
Note: The corresponding author has had access to all data and accepts the responsibility of submitting this manuscript for publication.
Warning: The content engages only the responsibility of their authors and does not necessarily represent the official views of the National Institutes of Health (NIH), the WHO or the Mbadachusetts General Hospital (MGH).
Recognition: The authors thank Taige Hou, software engineer CEPAC, for her important contributions to CEPAC models. They also thank the CEPAC-pediatric and CEPAC-International research teams for their role in the development and revision of models.
Financial aid: By the NIH through the National Institute of Allergy and Infectious Diseases (NIAID) (T32 Grants AI007433, R37 AI058736, R01 AI042006 and R37 AI093269) and the National Institute of Child Health and Development Human (NICHD) Eunice Kennedy Shriver (Grant R01 HD079214)), and by the Steve and Deborah Gorlin Research Award Scholars Award. This research was funded in part by a 2017 development grant from the Harvard University AIDS Research Center (CFAR), an NIH-funded program (grant P30 AI060354), supported by the Institutes and NIH co-funded centers: NIAID; National Cancer Institute; NICHD; National Institute of Dental and Craniofacial Research; National Institute of the Heart, Lungs and Blood; National Institute on Drug Abuse; National Institute of Mental Health (NIMH); National Institute on Aging; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; National Institute on Minority Health and Disparities in Health; Fogarty International Center; and Office of AIDS Research.
Disclosures: Dr. Dugdale mentions Harvard University's NIAID and Harvard grants while conducting the study, as well as NIMH and NIH / IMPAACT grants outside of the submitted work. Dr. Ciaranello announced that grants had been awarded by the NIH during the study, as well as by the Elizabeth Glaser Pediatric AIDS Foundation, the Foundation for AIDS Research (amfAR) and WHO, outside submitted works. Dr. Bekker reports Merck's personal fees and Gilead's free medication for demonstration studies outside the submitted work. Dr. Sax reports non-financial support from Bristol-Myers Squibb, grants and personal expenses from Gilead and ViiV / GlaxoSmithKline, as well as Janssen and Merck's own costs, outside the submitted work. Dr. Abrams reports ViiV's personal expenses outside the submitted work. Dr. Freedberg mentions grants awarded by the NIH, the Elizabeth Glaser Pediatric AIDS Foundation and WHO / Unitaid during the study, as well as grants awarded by the NIH outside the submitted work. Dr. Walensky announced NIH grants and was researcher Steve and Deborah Gorlin MGH during the study. The unnamed authors here have revealed no conflict of interest. Disclosures can also be found at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M18-3358.
Disclosures of the editors: Christine Laine, MD, MPH, editor-in-chief, says his wife holds stock / badet purchase options with targeted diagnoses and therapies. Darren B. Taichman, MD, PhD, editor, says that he has no financial relationship and no interest in disclosing. Cynthia D. Mulrow, MD, MSc, Associate Editor, says she has no relationship or interest in disclosing. Jaya K. Rao, MD, MHS, Associate Editor, says she has stock / options to buy in Eli Lilly and Pfizer. Catharine B. Stack, PhD, MS, Associate Editor of Statistics, says she owns shares in Pfizer, Johnson & Johnson and Colgate-Palmolive. Christina C. Wee, MD, MPH, Associate Editor, reports a job at Beth Israel Deaconess Medical Center. Sankey V. Williams, MD, deputy editor, says that he has no financial relationship and no interest in disclosing. Yu-Xiao Yang, MD, MSCE, deputy editor, says that he has no financial relationship nor any interest in disclosing.
Repeatable Research Statement:Study protocol: Not applicable. Statistical code: An example template code is available at www.mbadgeneral.org/mpec/cepac/. Dataset: Comprehensive data on the effectiveness of antiretroviral therapy and model inputs are available in Extra charge (available on Annals.org).
Corresponding author: Caitlin M. Dugdale, MD, Center for Evaluating Medical Practice, 100 Cambridge Street, Suite 1600, Boston, MA 02114; email, [email protected].
Address of the current author: Drs. Dugdale, Freedberg and Walensky and Mrs. Stern: Center for Evaluating Medical Practice, 100 Cambridge Street, Suite 1600, Boston, MA 02114.
Dr. Ciaranello: Center for Evaluating Medical Practices, 100 Cambridge Street, Room 1670, Boston, MA 02114.
Dr. Bekker: Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa.
Dr. Myer: Division of Epidemiology and Biostatistics, School of Public Health and Family Medicine, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa.
Dr. Wood: HIV Desmond Tutu Center, University of Cape Town, Anzio Road, Observatory 7925, Cape Town, South Africa.
Dr. Sax: Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115.
Dr. Abrams: Mailman School of Public Health, 722 West, 168th Street, New York, NY 10032.
Author contributions: Design and Design: C.M. Dugdale, A. L. Ciaranello, M. E. Stern, R. Wood, P. E. Sax, K. A. Freedberg, R. P. Walensky.
Data Analysis and Interpretation: C.M. Dugdale, A. L. Ciaranello, L. G. Bekker, M. E. Stern, L. Myer, R. Wood, P. E. Sax, E. J. Abrams, K. A. Freedberg, R. P. Walensky.
Article Writing: C.M. Dugdale, A.L. Ciaranello, L. Myer, P.E. Sax, R.P. Walensky.
Critical Review of Important Intellectual Content: C. M. Dugdale, A. L. Ciaranello, L. G. Bekker, L. Myer, R. Wood, P. E. Sax, E. J. Abrams, K. A. Freedberg, R. P. Walensky.
Final approval of the article: C.M. Dugdale, A. L. Ciaranello, L. G. Bekker, M. E. Stern, L. Myer, R. Wood, P. E. Sax, E. J. Abrams, K. A. Freedberg, R. P. Walensky.
Supply of study materials or patients: L.G. Bekker, L. Myer, R. Wood.
Statistical Expertise: A. L. Ciaranello, K. A. Freedberg, R. P. Walensky.
Obtaining funding: A. L. Ciaranello, K. A. Freedberg, R. P. Walensky.
Administrative, technical or logistical badistance: A.L. Ciaranello, M.E. Stern.
Collection and badembly of data: C.M. Dugdale, A. L. Ciaranello, M. E. Stern, L. Myer, R. Wood, P.E. Saxo.
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