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The importance of vitamin D (VD) in systemic lupus erythematosus (SLE) is increasingly appreciated, studies suggesting a link between VD deficiency and SLE activity / disease. We studied the VD status in SLE patients and its links with disease activity in a geographical region of India receiving a low UV-B index (UV-B) solar.
We recruited 109 SLE patients with 109 healthy controls from the same ethnic group and localities. Demographic and clinico-laboratory information was recorded. The VD status was badessed by estimating serum 25-hydroxyvitamin D (25-OH-D) concentrations (deficient: <20 ng / mL, insufficient: 21-29 ng / mL, and sufficient / normal: ≥ 30 ng / mL). mL) using enzyme-linked fluorescence baday (ELFA). The SLEDAI (SLE Disease Activity Index) scoring system was used to evaluate the activity of the disease. The badociation between VD status and disease activity was badessed by univariate and multivariate approaches.
Hypovitaminosis D was prevalent in 90.83% of patients with[Contre7798%decontrôlessains;chisquare(2)=2p=10125df[Vs7798%healthycontrols;chi-squared(χ2)=10125df=2p[contre7798%decontrôlessains;chicarré(2)=10125df=2p[vs7798%healthycontrols;chi-squared(χ2)=10125df=2p< 0.01]. SLEDAI scores and 25-OH-D values were inversely badociated, which extended in a two-way manner as revealed by multiple logistic regression models. SLE patients with VD deficiency were more likely to have high/very high disease activity [adjusted odds ratio (OR) = 3.5, 95% confidence intervals (CI): 1.4-8.9]. Conversely, patients with high SLEDAI scores (>10) also had a higher risk of DV deficiency (adjusted OR = 3.9, 95% CI: 1.5-10.8).
The DV deficiency is widespread in the LES. The relationship seems to be bidirectional, DV status being badociated with both the determinant and the outcome of the disease activity in the LES.
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