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A new study presented this week at the European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) in Amsterdam, the Netherlands, shows that a formulation containing zinc oxide is effective in reducing armpit odors by eliminating responsible bacteria and helping to heal wounds.
The study was conducted by Prof. Magnus S. Ågren, Copenhagen Wound Treatment Center, Bispebjerg Hospital, Copenhagen, Denmark (where the study took place) and by Khaled Saoud Ali Ghathian, Department of Clinical Microbiology, Hvidovre Hospital, Hvidovre, Denmark and his colleagues.
A foul odor of the armpit (under the armpit) is in most cases
caused by Corynebacterium spp. and Staphylococcus spp. the
The antimicrobial effects of zinc oxide (ZnO) have been largely
documented. In experimental studies, ZnO prevented the generation of bacteria
short chain fatty acids with a bad smell. In addition, topical ZnO
reduces the frequency of corynebacteria and unpleasant odors in the open air
surgical wounds, which gave researchers the idea of testing the
Compose directly on the body odor.
The armpit is hot, moist and rich in nutrients.
conditions that increase the pH. Because the solubility of ZnO is
Depending on the pH, the effectiveness may vary depending on the pH of the skin surface.
In addition, there is no consensus on the effect of genus on axillary pH
level.
The main objective of this double-blind, placebo-controlled trial
(ZINC-ON) was to investigate whether repeated application of ZnO formulated in a
an oil-in-water emulsion reducing armpit odors in healthy volunteers. the
badociation with the overall bacterial growth and in particular of
Corynebacterium spp. and S. hominis has also been studied. PH of the skin
was monitored in parallel. Second, anti-inflammatories and
The healing effects of topical ZnO were studied by evaluating the
extent of erythema and cutaneous evolution of keratin in two standard wounds
models: the one inflicted by a contact-activated lancet producing small
bleeding wounds and the other was induced by ablative CO2 laser
producing dry erosions in the skin.
The trial included 30 healthy volunteers (15 women / 15 men) of average weight
age 25.6 years. The left and right axilli of the participants were randomized
ZnO or placebo and treated for 13 consecutive days with 5
visits to the hospital. Participants were registered, stamped and
started treatment the day minus 8; at day 0, bacterial swabs were obtained
again and the injuries were inflicted and then the participants were seen on
days 3, 4 and 5. At the last visit, the participants were invited
(1) If they had observed a difference in the odor on the left
and the right axilles and, where appropriate, (2) to indicate which axis they judged
superior when it comes to odor.
ZnO treatment reduces the perceived unpleasant smell compared to
placebo. Overall bacterial growth and in particular the
Corynebacterium spp. generating odors. and S. hominis have been reduced with
ZnO treatment despite the increased pH of the skin surface (all
statistically significant). Topical ZnO reduces erythema peri-sore
(redness) around the wounds caused by the lancet and promoted the formation of
keratin.
The authors conclude: "The daily application of ZnO reduces odors
axillary and causative bacteria, increased pH of the cutaneous surface and
attenuated inflammation of the wound. "
Professor Ågren said: "The most common response we have had is
The participants were: "Where can I buy this fantastic product?" Even if
it did not contain any scents like conventional deodorants,
participants could identify that he had neutralized any bad smell under
the arm where it was applied. The product has since evolved into
marketing by Colgate-Palmolive, which manufactured the product and
sponsored this essay. "
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