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Montreal, April 16, 2019 – A new study conducted by a team from the Research Institute of the McGill University Health Center (RI-MUHC) may present an increased risk of type 1 diabetes in mothers with gestational diabetes the pregnancy that was published in the Journal of the Canadian Medical Association (CMAJ).
Early detection of diabetes is important in children and youth, as approximately 25% of them are diagnosed when they seek care for diabetic ketoacidosis, a life-threatening complication of diabetes that may occur when the body starts to run out of insulin.
"Although type 1 and type 2 diabetes in parents is a well established risk factor for their offspring to become diabetic, we show in this study that gestational diabetes may also be a risk indicator for type 1 diabetes. in the mother's children, the child or adolescent whose mother had gestational diabetes was almost twice as likely to develop type 1 diabetes before the age of 22, explains Dr. Kaberi Dasgupta, lead author of the study, director and principal investigator of the Center for Research and Evaluation Outcomes (CORE) at the RI-MUHC and badociate professor of medicine at the McGill University.
The study of 73,180 mothers compared Quebec data (1990-2012) on randomly selected single births of mothers with gestational diabetes to births to mothers without gestational diabetes. The incidence – the number of new cases – of diabetes per 10,000 person-years was 4.5 in children born to mothers with gestational diabetes and 2.4 in mothers without.
"Only a small number of children will develop diabetes before the age of 22, even if their mother has gestational diabetes," said co-author of the study, Dr. Meranda Naklha, pediatric endocrinologist at the Montreal Children's Hospital of the MUHC and badistant professor of pediatrics at McGill University. "However, parents and health care professionals should consider the possibility of diabetes if children begin to show signs such as frequent urination, excessive thirst or weight loss, especially if their mother has diabetes." gestational. "
According to the authors, the reasons for this relationship should be explored in future studies, but evidence of this link could help accelerate the diagnosis of diabetes in young people.
"This study is important because we are trying to understand the risk factors for type 1 diabetes," says Dr. Jan Hux, President and CEO of Diabetes Canada, who funded the research. "This research could further encourage health care providers to quickly test children with typical diabetes symptoms and born to mothers with gestational diabetes, thereby reducing the risk of serious incidents such as diabetic ketoacidosis." We look forward to improving children's living conditions and outcomes through further research in this area. "
Diabetes: type 1 or type 2 (source: Diabetes Canada)
Type 1 diabetes usually develops during childhood or adolescence, but can also develop in adulthood. People with type 1 diabetes are not able to produce their own insulin (and can not regulate their blood sugar) because the body's immune system attacks the pancreas. About 10% of people with diabetes have type 1 insulin-dependent diabetes.
Type 2 diabetes is most often developed in adulthood, although it can also occur during childhood. People with type 2 diabetes can not properly use insulin produced by their body, or their body is not able to produce enough insulin. About 90% of people with diabetes have type 2 diabetes.
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About the study:
Gestational Diabetes Associated with Incidental Diabetes in Children and Youth: A Retrospective Cohort Study
Andrea L. Blotsky, M.Sc., Elham Rahme, Ph.D., Mourad Dahhou, M.Sc. Meranda Nakhla, MSc, Kaberi Dasgupta, M.Sc.
doi: 10.1503 / cmaj.181001
This study was funded by an operating grant from Diabetes Canada (lead investigator Kaberi Dasgupta, co-principal investigator Elham Rahme).
Media contact:
Julie Robert
The communications
McGill University Health Center
Tel .: 514 934-1934 ext. 71381
Cell phone: 514 971-4747
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