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A recent study has baderted that oral immunotherapy administered as a routine treatment was safe for preschoolers allergic to peanuts. Oral immunotherapy (OIT) is a treatment protocol in which a patient consumes small amounts of allergenic food.
"Although many clinical trials on peanut oral immunotherapy have been conducted in older children and one trial in preschool children, there has been a lack of real data because of the safety concerns badociated with providing this treatment to preschool children outside of the research setting, "said Lianne Soller, the lead author of the study published in the Journal of Allergy and Clinical Immunology.
A pediatric allergist saw children every two weeks and gave them a dose of peanuts that gradually increased with each visit. Parents also gave children the same daily dose at home, between visits to the clinic, until they reached a maintenance dose of 300 mg of protein. peanut. The symptoms and treatment of allergic reactions during clinic and home visits, including the use of epinephrine, have been documented in the patient's medical record.
Parents were given instructions on how to manage allergic reactions at home, when to administer epinephrine and when to take a dose of the ILO, for example during a cold or from a severe flu. "The goal of our project was to confirm the safety of the ILO's pre-school peanut in a much larger sample of patients in the real world," said Dr. Edmond Chan, lead author. The researchers found that 243 children (90%) had reached the stage of the interview successfully, while 27 children, or 10%, had dropped out of school.
It took an average of 22 weeks of oral immunotherapy for patients to reach the maintenance stage. Many allergists believe that the ILO should not be offered outside of the research setting and has not consistently proposed it as a peanut allergy treatment in their clinics security concerns. We hope that our data demonstrate that the treatment is safe for preschool children and that it could be offered to families of peanut-allergic preschoolers who request it.
There seems to be a big difference in the results of preschool children compared to older children, "he said. The group now hopes to study the long-term safety and effectiveness of the ILO's desensitization of peanut and the lack of sustained reactivity of patients who choose to discontinue daily P & P. # 39; peanut OIT. "He hopes the results will provide advice to health practitioners treating preschoolers in their clinics," Chan said.
Posted: 21st April 2019 3:29 pm
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