Immunization coverage against HPV is far behind other childhood vaccines

Despite the upward trend in uptake, vaccination coverage against human papillomavirus (HPV) is much lower than other infant vaccines in many states, according to a new study describing trends in uptake of HPV vaccine in children in the United States. presented at the 2019 Pediatric Academic Societies (PAS) meeting, which will take place from April 24 to May 1 in Baltimore.

In this cohort study of more than 7.5 million children in the United States, HPV vaccination coverage among 15-year-old girls and boys increased from 38% to 5% in 2011 compared with the previous year. 54% to 45% in 2016, "said Szu-Ta Chen. , MD, one of the authors of the study. "Despite the increase in uptake, HPV vaccine coverage varied considerably between states and remained below the 80% target of Healthy People 2020."

The researchers identified a cohort of children in the Truven MarketScan health care database between January 2003 and December 2016. Children were followed from the age of 9 until they reached the age of 9. the first dose of HPV vaccine, the death, the end of the insurance coverage or the end of the year they were 17 years old, whichever comes first. The first dose of HPV vaccination was verified by current procedural terminology codes (CPT). The monthly vaccination rate was calculated by dividing the number of children who received the HPV vaccine during that month divided by the sum of the person-months paid by eligible children that month. The cumulative incidence of HPV vaccination was estimated based on the monthly vaccination rate with the help of a survival badysis. The study population was stratified by year of birth and bad. The cumulative incidence of HPV vaccination at age 15 has been mapped in 50 states.

The study included 7,500,397 children (49% female) and 18.8 million person-years. In 2011, the proportion of 15-year-olds vaccinated with at least one dose of HPV was 37.8% for girls and 4.8% for boys (1996 birth cohort) ; in 2016, this proportion had increased to 53.6% for girls and 45.1% for boys (birth cohort in 2001). HPV vaccine uptake varied considerably from one state to another, and in 2016, it exceeded 60% for girls and boys aged 15 only in 13 and three states, respectively.

The Advisory Committee on Immunization Practices recommends HPV vaccination at 11 and 12 years of age to prevent HPV infection and the subsequent occurrence of various cancers. There is no large-scale longitudinal data on trends in vaccine uptake in the United States.

Mr. Chen will present the results of "Human Papillomavirus Vaccine Trends for Girls and Boys in the United States: 2003 to 2016 Evidence," on Monday, April 29.

Source: Pediatric Academic Societies