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The research was presented at Digestive Diseases Week.
EndoPil, measuring approximately 3 cm by 1 cm, has an outer gelatin shell containing a deflated balloon, a magnetized inflation valve, and a harmless acid and salt stored in separate compartments in one compartment. internal capsule.
Designed to be swallowed with a glbad of water, the capsule gets into the stomach. The acid located inside the breaks opens the gelatin capsule outer shell.
Its location in the stomach is determined by a magnetic sensor. An outer magnet 5 cm in diameter is used to attract the magnet attached to the inflation valve and open it. This mechanism avoids premature swelling of the device in the esophagus or delayed inflation after its entry into the small intestine.
"Opening the valve allows the acid and salt to mix and react, producing carbon dioxide to fill the flask." The safe ingredients for the kitchen were chosen to ensure the safety of the capsule, "said Louis Phee, one of the researchers.
When the balloon expands with carbon dioxide, it floats up the stomach, the most sensitive part to fullness. Within three minutes, the balloon can be inflated to 120 ml. It can be magnetically deflated to a size small enough to enter the small intestine.
Its magnetically activated inflation mechanism causes a reaction between a harmless acid and a salt stored in the capsule, which produces carbon dioxide to fill the balloon.
"Such a self-inflating weight loss capsule, administered orally, could represent a non-invasive alternative to combat the growing global epidemic of obesity," said Phee.
Another alternative chosen by moderately obese patients and those who are too sick to undergo surgery is an intragastric balloon, a proven weight loss intervention that must be inserted into the stomach by endoscopy under sedation.
It is removed six months later via the same procedure. As a result, not all patients are open to this option because the balloon must be inserted into the stomach by endoscopy and sedation.
It is also common that patients who opt for the intragastric balloon have nausea and vomiting, up to 20% requiring early removal of the balloon due to intolerance. The stomach can also get used to prolonged placement of the balloon inside, which makes it less effective for losing weight.
The viability of EndoPil was first tested in a preclinical study during which a larger prototype was inserted into a pig. The results showed that the pork with the capsule inflated in the stomach lost 1.5 kg a week later, while a control group of five pigs gained weight.
"The main benefit of EndoPil is its simplicity of administration.You only need a glbad of water to help it get off and d & # 39; A magnet to activate it.We are now trying to reduce the size of the prototype and improve it with a natural decompression mechanism We expect that such features will help the capsule to be widely accepted and will benefit the patients with obesity and metabolic diseases, "added Phee.
Professor Lawrence Ho, a researcher, said: "The compact size and simple activation of EndoPil with the help of a portable external magnet could pave the way for an alternative that could to be administered by physicians even as an outpatient and as part of primary care hospitalization and savings for patients and the health system. "
Each capsule should be removed within one month, which will shorten the treatment cycles to prevent the stomach from getting used to the presence of the balloon.
As the saturation effect of the stomach progresses, it is possible to avoid the side effects of sudden inflation, such as vomiting and discomfort.
The team is currently working on programming the capsule for it to biodegrade and deflate after a set amount of time, before being expelled by the body's digestive system. This includes the incorporation of a deflation plug at the end of the inner capsule which can be dissolved by the acid from the stomach, thereby allowing the carbon dioxide to escape. In case of emergency, the balloon can be deflated to order with an external magnet.
National Nutrition Week: Keto, Paleo, GM, the most effective diets to lose weight
Need nutrition
September 4, 2018
In a world of convenience, where people prefer a bowl of instant noodles to a whole-grain chapatti, nutrition seems to have disappeared from our plates. And thanks to such practical options, the incidence of obesity has also exploded.
For all those who have surpbaded their healthy index and are overweight / obese, weight loss is becoming one of the main targets.
In this National Nutrition Week, we offer 5 diet plans that will help you lose weight in a healthy way.
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