A study adds to the evidence that other factors lead to an increase – ScienceDaily

CRC incidence rates are declining rapidly in adults over age 55 in the United States, in part because of the widespread absorption of colonoscopy, which can suppress precancerous growths and reduce rates of infection. # 39; impact. In contrast, the incidence of RCCs in young adults is increasing.

The question of whether the increase in incidence in younger adults reflects a real increase in the disease, or rather an increased detection as a result of the multiplication of colonoscopies over time.

To shed light on this debate, researchers from the American Cancer Society led by Stacey Fedewa, Ph.D. determined colonoscopy rates over the past year among more than 50,000 respondents aged 40 to 54 years old. 39, after data from the National Health Interview Survey. Colorectal cancer incidence rates and incidence rate ratios were calculated based on 18 surveillance epidemiology and population-based end-of-period registers over the same time period. .

Between 2000 and 2015, colonoscopy rates over the past year were relatively stable among people aged 40 to 44 (less than 3%), while colorectal cancer incidence rates were increased by 28%. In the 45 to 49 age group, colonoscopy rates doubled (from 2.5% in 2000 to 5.2% in 2015), while colorectal cancer incidence rates increased by 15%. Between the ages of 50 and 54, colonoscopy rates increased 2.5-fold (from 5.0% to 14.1%), while incidence rates increased by 17%.

If the increasing incidence of newly emerged CRCs was the result of greater detection, one could expect a greater increase in the number of early stage diagnoses because screening is the most likely to detect localized disease. To investigate this, the researchers examined trends in the incidence of CRC by phase from 2000 to 2015. Increases for localized disease occurred in the 40-44 age group, in whom colonoscopy was stable. but not among those aged 45 to 49 years, in whom colonoscopy had increased. However, the disease at the distant stage increased in all age groups and was higher (2.9% per year) than that of the localized stage (1.1% per year) among 40-44 year olds.

"The changes in colonoscopy rates over the past year did not fully match the increase in colorectal cancer incidence rates at the general and distant stage in the three age groups at the time. during the corresponding period, "said Dr Fedewa. "There were concordant patterns, such as increased colonoscopy and early-stage incidence in the 50-54 age group, but also discordant patterns, such as lack of increase colonoscopy in people in their early forties to match increasing CRC rates in this age group. "

"Future studies should examine the reasons for the increase in CRC incidence rates among young adults," the study concludes.

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