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The researchers said the patch had been optimized with the help of a computer model of the heart.
The researchers have come up with a new adhesive patch that could reduce the stretching of the heart muscle after a heart attack.
Developed by a team of researchers from Brown University, USA; The University of Fudan, China, and Soochow University, China, the patch is made from water-based hydrogel and can be placed directly on the heart to prevent left ventricular remodeling – a stretch heart muscle.
A heart attack exposes the heart muscle to a risk of stretching that can reduce the functioning of the main pumping chamber of the heart.
"One of the reasons why it is difficult for the heart to recover after a heart attack is that it must continue to refuel," said co-author Huajian Gao, a professor at Brown University. .
"The idea here is to provide mechanical support for damaged tissue, which gives them a chance to heal," he added.
The researchers said the patch, which costs "less than a penny", was optimized using a computer model of the heart to perfectly match the mechanical properties of the material.
"If the material is too hard or too stiff, then you can limit the movement of the heart so that it can not expand to the necessary volume," Gao said.
"But if the material is too soft, it will not provide enough support, so we need mechanical principles to guide us," he said.
For the research, published in Nature Biomedical Engineering, the team tested the patch on rats and showed that it could be effective in reducing the damage following a heart attack.
"The patch provided almost optimal mechanical supports after myocardial infarction (ie, mbadive death of cardiomyocytes)," said co-author Ning Sun, a researcher in cardiology at the university. from Fudan.
"[It] maintained better cardiac output and thus significantly reduced the overload of these remaining cardiomyocytes and adverse cardiac remodeling. "
The researchers say the early results are promising for potential use in human clinical trials.
"It remains to be seen if it will work in humans, but it is very promising," Gao said.
Indo-Asian Information Service
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