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When a transplant is performed, recipients must take long-term anti-rejection drugs that inhibit the body's immune system. However, anti-rejection drugs are known to cause serious infections and even cancer in recipients. Now, researchers have found a way to eliminate the need for anti-rejection drugs.
In the study published in Nature Communications, the researchers maintained the long-term survival and function of pancreatic islet transplants despite complete cessation of all anti-rejection drugs on the 21st day after transplantation.
The new study builds on the unique attributes of modified donor white blood cells, which have been infused into transplant recipients a week before and a day after transplantation, summing up the formula of nature that maintains the body's tolerance to its transplantation. own tissues and organs.
Without the need for long-term anti-injection drugs, islet cell transplants could become the treatment option of choice or even the cure for many people with type 1 diabetes.
"Our study is the first to reliably and safely induce long-lasting immune tolerance of transplants in non-human primates," said lead author Bernhard Hering, professor and vice-president of translational medicine at the Department of Surgery at the University of Ottawa. 39, University of Minnesota.
"The consistency with which we have been able to induce and maintain graft tolerance in non-human primates gives us great hope that our findings can be confirmed for the benefit of patients participating in planned clinical trials of islet transplants and pancreatic islets. donor kidneys living an entirely new era in transplant medicine. "
To prevent rejection of a transplant, recipients must take long-term medications that inhibit the body's immune system.
Immunosuppressive drugs are effective in preventing short-term rejection; However, as anti-rejection drugs suppress the immune system in a non-specific way, people who take these medications run the risk of serious infections and even cancer.
In addition, the non-immunological side effects of immunosuppression, such as hypertension, renal toxicity, diarrhea and diabetes, reduce the benefits of transplantation.
Finally, immunosuppressive drugs are much less effective in preventing rejection of a transplant over a long period of time, resulting in loss of transplant in many recipients.
Posted on: 3 Aug 2019 11:02
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