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It is increasingly thought that the microbiome is involved in cancer. A new multi-million dollar project led by US researchers aims to investigate this link with colorectal cancer. & Nbsp; Photo credit: Getty Royalty Free.Getty
The microbiome is apparently related to all aspects of our health and is today one of the largest charities fighting cancer, Cancer Research UK has spent up to $ 25 million to find out if he could be involved in colorectal cancer, the third most common cancer in the United States
Many lifestyle factors influence the risk of developing colorectal cancer. Researchers are discovering that the impact of some of these factors on the microbiome, such as diet and obesity, can play an important role in the development, progression and even the response to cancer drugs of colorectal cancer.
the ambitious project involves 14 researchers in six different countries, but is led jointly by two US researchers; Professor Matthew Meyerson of the Dana-Faber Cancer Institute and Harvard Medical School and Professor Wendy Garrett of Harvard T.H. Chan School of Public Health. Meyerson specializes in cancer genetics and Garrett's expertise in immunology and infectious diseases.
"The colon is the most densely populated microbial environment on the planet. Our tumors and cancers also harbor microbes that can help determine whether we respond to a drug or not. There are many opportunities to think about cancer, risk, development, treatment and cancer treatment across the microbiome, "says Garrett.
A bacterial species called Helicobacter pylori stomach cancer for a long time, but its connection with colorectal cancer is uncertain, although it exists growing evidence suggest that he is involved in some cases. There is also a great interest for bacteria in the normal intestinal microbiome, which currently do not seem to play any role in the disease.
"We and others have shown that bacteria can promote colon cancer in a number of model systems and if you treat these infections, it seems possible to limit the growth of these colon cancers." do not really understand this in detail and we do not have enough evidence to make that happen. " said Meyerson.
The team will use various experimental systems to investigate the possible relationship between bacteria and colorectal cancer, including animal models and organoids; small organs in a dish made from patients with colon cancer. The team will also examine the effect of current treatments on the microbiome on colorectal cancer by collecting samples of treated patients.
"With new genomic technologies, we can map the microbiome with incredible detail. The moment is therefore propitious to study this phenomenon of cancer. With this information, we hope to develop new therapies targeting the colorectal cancer microbiome, "says Meyerson.
This work is just beginning and time will tell if the team will reach a point where it has enough evidence that the microbiome is involved in colorectal cancer to consider trying to change it to treat or even prevent the disease, but they are well prepared. do this work if the first data is convincing.
"First of all, we have to take into account safety during any type of intervention.We have several clinical trials involved in the study and a whole network of clinical trials supporting this network and ready to intervene. , "said Garrett.
The ambitious quinquennial projects will be directed jointly by MM. Matthew Meyerson and Wendy Garrett.Sam Ogden, photographer Dana-Farber Cancer Institute
Cancer Research UK, which has historically funded researchers based in UK hospitals and universities, is diversifying to fund the "Big Challenges", which combine traditionally separate research areas to deliver innovative solutions to the key challenges of cancer research. cancer research.
"The big challenge of Cancer Research UK is different from almost every other research fund, in that it aims to bring together the best minds in various disciplines and around the world to focus on specific challenges in cancer research. We have received 134 applications from 41 different countries, which have been ranked among the last three projects in this year's funding cycle, "Iain Foulkes, PhD, Executive Director of Research and Innovation, Cancer Research UK.
The other two projects aim to find new ways to fight cancers caused by chronic inflammation and to better understand why cancers develop in some tissues, but not in others. Both are also led by researchers based in the United States, with funding provided for the three projects totaling approximately $ 75 million.
"Cancer is a global problem that requires a comprehensive solution. The quality of the apps has proven that the best science occurs when top scientists work collaboratively with each other, "says Foulkes.
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It is increasingly thought that the microbiome is involved in cancer. A new multi-million dollar project led by US researchers aims to investigate this link in colorectal cancer. Photo credit: Getty Royalty Free.Getty
The microbiome is apparently related to all aspects of our health. Today, Cancer Research UK, one of the world's largest cancer charities, has committed up to $ 25 million to determine whether it is colorectal cancer, the third cancer the most widespread in the world. WE
Many lifestyle factors influence the risk of developing colorectal cancer. Researchers are discovering that the impact of some of these factors on the microbiome, such as diet and obesity, can play an important role in the development, progression and even the response to cancer drugs of colorectal cancer.
This ambitious project involves 14 researchers from six different countries, but is conducted jointly by two US researchers. Professor Matthew Meyerson of the Dana-Faber Cancer Institute and Harvard Medical School and Professor Wendy Garrett of Harvard T.H. Chan School of Public Health. Meyerson specializes in cancer genetics and Garrett's expertise in immunology and infectious diseases.
"The colon is the most densely populated microbial environment on the planet. Our tumors and cancers also harbor microbes that can help determine whether we respond to a drug or not. There are many opportunities to think about cancer, risk, development, treatment and cancer care through the lens of the microbiome, "Garrett said.
A bacterial species called Helicobacter pylori Stomach cancer has long been accepted as a cause of stomach cancer, but its relationship to colorectal cancer is uncertain, although growing evidence suggests that it is involved in some cases. There is also a great interest for bacteria in the normal intestinal microbiome, which currently do not seem to play any role in the disease.
"We and others have shown that bacteria can promote colon cancer in a number of model systems and if you treat these infections, it seems possible to limit the growth of these colon cancers." We do not understand really this in detail right now and if there is enough evidence for that to happen in people. " said Meyerson.
The team will use various experimental systems to study the possible relationship between bacteria and colorectal cancer, including animal models and also organelles; Tiny organs in a dish made from patients with colon cancer. The team will also examine the effect of current treatments on the microbiome on colorectal cancer by collecting samples of treated patients.
"With new genomic technologies, we can map the microbiome with incredible detail. The moment is therefore propitious to study this phenomenon of cancer. With this information, we hope to develop new microbiome-targeted therapies for colorectal cancer, "said Meyerson.
This work is just beginning and time will tell if the team will reach a point where it has enough evidence that the microbiome is involved in colorectal cancer to consider trying to change it to treat or even prevent the disease, but they are well prepared. do this work if the first data is convincing.
"First and foremost, we need to consider safety in any intervention, we have several clinical trials involved in the study and a complete network of clinical trials supporting this network and ready to respond," Garrett said.
The ambitious quinquennial projects will be directed jointly by MM. Matthew Meyerson and Wendy Garrett.Sam Ogden, photographer Dana-Farber Cancer Institute
Cancer Research UK, which has historically funded researchers based in UK hospitals and universities, is diversifying to fund the "Big Challenges", which combine traditionally separate research areas to deliver innovative solutions to the key challenges of cancer research. cancer research.
"The big challenge of Cancer Research UK is different from almost every other research fund, in that it aims to bring together the best minds in various disciplines and around the world to focus on specific challenges in cancer research. We have received 134 applications from 41 different countries, which have been reduced to the last three projects for this year's funding cycle, "said Iain Foulkes, PhD, executive director of cancer research and innovation at Cancer Research. UK.
The other two projects aim to find new ways to fight cancers caused by chronic inflammation and to better understand why cancers develop in some tissues, but not in others. Both are also led by researchers based in the United States, with funding provided for the three projects totaling approximately $ 75 million.
"Cancer is a global problem that requires a comprehensive solution. The quality of applications has proven that the best science occurs when top scientists work collaboratively with each other, "said Foulkes.
