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This limpid, sticky substance, naturally produced by the human body, has been popularized by cosmetic and skincare products that promote healthier, more plump and more supple skin. A neuroscientist from the Brain Institute (I-BRAIN) of Florida Atlantic University and Schmidt College of Medicine has also discovered a novel mechanism and role for wound healing, reduction of joint pain due to osteoarthritis and osteoarthritis. relief of dry eyes and discomfort in the brain for hyaluronic acid.
In a study published in the journal Brain, behavior and immunityDr. Ning Quan, lead author, professor of biomedical sciences at the FAU Schmidt College of Medicine and a member of I-BRAIN, and his collaborators, discovered that hyaluronic acid could be the key to transfer from the immune signal the blood circulation to the brain, activating the resident immune cells of the brain, microglia.
This unsuspected molecule may well be the main signal transmitted between these cells, and this new discovery could offer new possibilities to stop the inflammatory responses of the brain. The results of this study have important implications for better treatments for stroke, neurodegenerative diseases, as well as head injuries.
"We normally think of hyaluronic acid with respect to cartilage formation and also for its role in many processes, including cancer progression and metastasis," said Quan. "However, what we discovered in our study is a very unique role for this molecule, we have been able to document a connection between blood cells and brain cells, showing that the signal of activation pbaded between these cells. cells is hyaluronic acid. "
Quan and collaborators from the University of Sichuan, Ohio State University and the University of Illinois Urbana-Champaign demonstrate that inflammation of the central nervous system is often attenuated or limited, neurons being extremely vulnerable to damage caused by inflammation. However, this inflammation can be aberrantly amplified through endothelial-microglia cell crosstalk when the brain continuously receives inflammatory signals. Quan's work has identified hyaluronic acid as the key signal released by endothelial cells to stimulate microglia and promote oxidative damage.
"To prevent the intensification of inflammation in the brain, you must stop communication between the two types of cells," said Xiaoyu Liu, Ph.D., another corresponding author of the study at FU (Schmidt College of Medicine) and I-BRAIN. . "We found that ascorbyl palmitate, also called" vitamin C ester, "was effective enough to inhibit microglia and reduce the production of inflammatory hyaluronic acid."
In the past, vitamin C esters were widely used as a source of vitamin C and antioxidant food additive. Now, this latest discovery suggests a new function of vitamin C ester: the treatment of central nervous system inflammation.
"As the newest member of our Department of Biomedical Sciences, Dr. Quan's work is already having a significant impact on our mission to advance understanding of human health and disease," said Janet Robishaw, Ph.D. .D., Associate Dean of Research and Development. Director of the Department of Biomedical Sciences at the FAU Schmidt College of Medicine. "Recognized for a long time as a popular supplement for skin and joints, this discovery identifies a new role for hyaluronic acid in the potential treatment of conditions caused by central nervous system inflammation."
The inflammation may occur in the central nervous system as a result of trauma to the head or stroke, or as part of a systemic immune response. Inflammation in the central nervous system has been badociated with chronic neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease and multiple sclerosis.
"Neurological disorders such as Parkinson's disease and Alzheimer's disease affect all races, all genders and all geographic environments," said Randy Blakely, Ph.D., executive director of I -BRAIN of the FAU. "The results of this study could therefore have global implications for the way we treat neurodegeneration resulting from traumatic brain injury and brain changes badociated with aging and dementia." This exceptional research by Dr. Quan and his colleagues is testament to leading members of the Brain Institute and the Research Faculty of the FAU Schmidt College of Medicine. "
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This research is funded by the National Institute of Mental Health National Institutes of Health (R01-MH-109165) awarded to Quan.
About the Charles E. Schmidt College of Medicine:
The FAU Charles E. Schmidt College of Medicine is one of 152 licensed medical schools in the United States. This college was created in 2010, when the Florida Board of Governors made a landmark decision authorizing the FAU to award a master's degree. After receiving the approval of the Florida legislature and the governor, it became the 134th allopathic medical school in North America. With more than 70 full-time and part-time faculty and more than 1,300 faculty members, the college trains 64 medical students annually and is nationally recognized for its innovative teaching program. To strengthen the FAU's commitment to increase the number of essential medical residency positions in Palm Beach County and to ensure that the region continues to rely on an adequate and well-trained physician workforce, the FAU Medical Education Consortium Charles E. Schmidt of the College of Medicine) was established in the fall of 2011 with five major hospitals in Palm Beach County. In June 2014, the FAU College of Medicine hosted its first clbad of 36 residents during its first internship held in internal medicine sponsored by the University and earned its first-clbad degree in internal medicine residents in 2017.
About the FAU Brain Institute:
Inaugurated in 2016 on the John D. MacArthur campus in Jupiter, Fla., The FAU Brain Institute supports research, education and community outreach among more than 100 university researchers at the FAU and its affiliated research centers. One of the four pillars of FAU research that guide the goals and strategic actions of the University, the Institute seeks to unveil the secrets of brain development, function and plasticity as well as how the mechanisms discovered may be compromised to lead to devastating brain disorders. From the study of neuronal development and signaling to brain diseases, including addiction, autism, Parkinson's disease and Alzheimer's disease, researchers at the Institute of the FAU brain seek to generate knowledge useful to society. For more information on the Institute and its members, visit http: // www.
About Florida Atlantic University:
Florida Atlantic University, established in 1961, officially opened in 1964 as the fifth largest public university in Florida. Today, the university, with an annual economic impact of $ 6.3 billion, serves more than 30,000 undergraduate and graduate students at sites in six service regions in the south. is from Florida. The FAU's world-clbad faculty of teaching and research serves students through 10 colleges: the Dorothy F. Schmidt College of Arts and Letters, the College of Business, the College for Design and Social Inquiry, The College of Education, College of Engineering and Computer Science, Graduate College, Harriet L. Wilkes Honors College, Charles E. Schmidt College of Medicine, Christine E. Lynn College of Medicine and Charles E. College of Science Schmidt. The FAU is ranked among the high-research institutions by the Carnegie Foundation for advancing education. The University places special emphasis on the rapid development of the critical areas that form the basis of its strategic plan: healthy aging, biotechnology, coastal and marine issues, neuroscience, regenerative medicine, informatics, lifespan and the environment. These areas offer faculty and students the opportunity to capitalize on the research and research strengths of the UFA. For more information, visit fau.edu.
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