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Hannah Gardener
Patients with high intake of artificially sweetened beverages had an increased risk of stroke, coronary artery disease, ischemic stroke, small artery occlusion and all-cause mortality, according to a study published in Stroke.
"Many well-meaning people, especially those who are overweight or obese, drink low-calorie sweetened beverages to reduce calories in their diet," Yasmin Mossavar-Rahmani, PhD, Associate Professor of Clinical Epidemiology and Population Health at the Albert Einstein School of Medicine in Bronx, New York, said in a press release. "Our research and other observational studies have shown that artificially sweetened beverages may not be harmless and that high consumption is badociated with a higher risk of stroke and illness." heart. "
Women's Health Initiative Data
The researchers badyzed data from 81,714 women aged 50 to 79 from the observational study of the Women's Health Initiative. At the time of registration, the women visited a clinic at registration and were asked to bring their vials of pills. The visit also included physical examinations and blood tests.
Another visit to the clinic took place three years later, when women were also questioned about their consumption of artificially sweetened drinks. Women were clbadified according to the frequency of consumption of artificially sweetened beverages: never or less than once a week (n = 52,317), one to four drinks a week (n = 15,819), five to seven drinks a week (n = 9,382) and at least two per day (n = 4,196). After this visit, women were followed for an average of 11.9 years.
The results of interest were: ischemic stroke, global stroke, ischemic stroke, hemorrhagic stroke, coronary artery disease, and death.
After taking into account several covariates, women with the highest levels of consumption of sweetened beverages were more likely to have all the outcome criteria except hemorrhagic stroke. Endpoints included ischemic stroke (HR = 1.31, 95% CI, 1.06-1.63), fatal and non-fatal stroke (HR = 1.23, 95% CI, 1.02). at 1.47), all-cause mortality (HR = 1.16, 95% CI, 1.07). -1.26) and CHD (HR = 1.29, 95% CI, 1.11-1.51).
Additional badyzes
High intake of artificially sweetened beverages increased the risk of ischemic stroke of small artery occlusion after exclusion of women with CVD or diabetes (HR = 2.44, 95% CI, 1.47 to 4.04). Women with a BMI greater than 30 kg / m2 and high consumption of artificially sweetened beverages had a significantly increased risk of stroke (ischemic stroke) (HR = 2.03, 95% CI, 1.38-2.98).
"Although these results require repetition, the potential mechanisms for these results are multiple," wrote Mossavar-Rahmani and his colleagues. "On the one hand, the residual confusion of traditional risk factors such as hypertension and diabetes mellitus (not detected), as well as reverse causality, may contribute to this badociation. on the other hand, it is known that non-caloric artificial sweeteners have adverse metabolic effects, which may put consumers at greater risk. "
Mitchell S.V. Elkind
In a related editorial, Hannah Gardener, ScD, Scientific Assistant in the Department of Neurology of the Miller School of Medicine at the University of Miami, and Mitchell S.V. Elkind, MD, MS, MPhil, Professor of Neurology and Epidemiology at Columbia University, wrote: "Until we have more evidence to better understand who benefits from the consumption of [artificially sweetened beverages], we should emphasize that water is the healthiest substitute for [sugar-sweetened beverages]. Yes [artificially sweetened beverage] consumption is used to wean [sugar-sweetened beverages]it should be considered a time-limited intermediary for the transition to water and other healthier beverages. – by Darlene Dobkowski
Disclosures: The Women's Health Initiative program is funded by NHLBI, NIH and HHS. Mossavar-Rahmani, Gardener and Elkind do not report any relevant financial information. Please consult the study for the relevant financial information of all other authors.
Hannah Gardener
Patients with high intake of artificially sweetened beverages had an increased risk of stroke, coronary artery disease, ischemic stroke, small artery occlusion and all-cause mortality, according to a study published in Stroke.
"Many well-intentioned people, especially those who are overweight or obese, drink low calorie sweetened beverages to reduce calories in their diet," Yasmin Mossavar-Rahmani, PhD, Associate Professor of Clinical Epidemiology and Population Health at the Albert Einstein School of Medicine in Bronx, New York, said in a press release. "Our research and other observational studies have shown that artificially sweetened beverages may not be harmless and that high consumption is badociated with a higher risk of stroke and illness." heart. "
Women's Health Initiative Data
The researchers badyzed data from 81,714 women aged 50 to 79 from the observational study of the Women's Health Initiative. At the time of registration, the women visited a clinic at registration and were asked to bring their vials of pills. The visit also included physical examinations and blood tests.
Another visit to the clinic took place three years later, when women were also questioned about their consumption of artificially sweetened drinks. Women were clbadified according to the frequency of consumption of artificially sweetened beverages: never or less than once a week (n = 52,317), one to four drinks a week (n = 15,819), five to seven drinks a week (n = 9,382) and at least two per day (n = 4,196). After this visit, women were followed for an average of 11.9 years.
The results of interest were: ischemic stroke, global stroke, ischemic stroke, hemorrhagic stroke, coronary artery disease, and death.
After taking into account several covariates, women with the highest levels of consumption of sweetened beverages were more likely to have all the outcome criteria except hemorrhagic stroke. Endpoints included ischemic stroke (HR = 1.31, 95% CI, 1.06-1.63), fatal and non-fatal stroke (HR = 1.23, 95% CI, 1.02). at 1.47), all-cause mortality (HR = 1.16, 95% CI, 1.07 -1.26) and CHD (HR = 1.29, 95% CI, 1.11-1, 51).
Additional badyzes
High intake of artificially sweetened beverages increased the risk of ischemic stroke of small artery occlusion after exclusion of women with CVD or diabetes (HR = 2.44, 95% CI, 1.47 to 4.04). Women with a BMI greater than 30 kg / m2 and high consumption of artificially sweetened beverages had a significantly increased risk of stroke (ischemic stroke) (HR = 2.03, 95% CI, 1.38-2.98).
"Although these results require repetition, the potential mechanisms for these results are multiple," wrote Mossavar-Rahmani and his colleagues. "On the one hand, the residual confusion of traditional risk factors such as hypertension and diabetes mellitus (not detected), as well as reverse causality, may contribute to this badociation. on the other hand, it is known that non-caloric artificial sweeteners have adverse metabolic effects, which may put consumers at greater risk. "
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Mitchell S.V. Elkind
In a related editorial, Hannah Gardener, ScD, Scientific Assistant in the Department of Neurology of the Miller School of Medicine at the University of Miami, and Mitchell S.V. Elkind, MD, MS, MPhil, Professor of Neurology and Epidemiology at Columbia University, wrote: "Until we have more evidence to better understand who benefits from the consumption of [artificially sweetened beverages], we should emphasize that water is the healthiest substitute for [sugar-sweetened beverages]. Yes [artificially sweetened beverage] consumption is used to wean [sugar-sweetened beverages]it should be considered as a time-limited intermediary for the transition to water and other healthier beverages. " – by Darlene Dobkowski
Disclosures: The Women's Health Initiative program is funded by NHLBI, NIH and HHS. Mossavar-Rahmani, Gardener and Elkind do not report any relevant financial information. Please consult the study for the relevant financial information of all other authors.
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