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NEW ORLEANS– Researchers who use the world's largest double-blind to study seven autoimmune diseases have found that the risk of developing these seven diseases is largely hereditary, but some diseases are more closely linked than any other disease. 39; others. These results will be presented Sunday at ENDO 2019, the annual meeting of the Endocrine Society in New Orleans, Louisiana.
"These findings contribute to our understanding of the causes of autoimmunity and the relationship between autoimmune diseases," said Jakob Skov, MD, principal investigator of the study and incumbent. a Ph.D. student at the Karolinska Institute in Stockholm, Sweden. "We examined the risk of contracting not only a specific disease, but also one of the diseases that are part of a group of conditions.The results could be useful for patient education and counseling. in the field of autoimmune risk ".
Autoimmune diseases tend to run in families. The basis of studies on twins is to examine concordance rates – the likelihood that both twins in a couple have the same illness. Higher concordance rates in twins identical to those in non-identical twins indicate a genetic influence. This information is generally used to calculate heritability – a measure of the magnitude of disease risk variation due to genetic factors. Skov and his colleagues also examined the likelihood that both twins in a pair would have different autoimmune diseases – which they termed "pseudoconcordance" – and compared these rates to measure autoimmune clustering.
Using data on 116,320 twins from the Swedish Registry Twin Registry, run by the Karolinska Institute, they discovered that Addison's disease, a type of adrenal insufficiency; celiac disease or gluten intolerance; and type 1 diabetes, are strongly influenced by genes whose heritability is greater than 85%, while environmental factors contribute to the hypothyroidism disease of Hashimoto, an underactive thyroid form ; vitiligo skin disease; Graves' disease, an overactive thyroid; and atrophic gastritis, chronic inflammation of the stomach.
The researchers found that autoimmune clustering was high in Addison's disease and vitiligo, but low in celiac disease.
"Our findings indicate that Addison's disease and vitiligo often overlap with other disorders, while celiac disease more rarely badociates with other diseases," Skov said.
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This research was funded by the County Councils of Värmland and Stockholm, the Swedish Society for Medical Research, the Ake Wiberg Foundation, the Swedish Research Council, the Torsten Soderberg and Ragnar Soderberg Foundations, the Novo Nordisk Foundation and the EU. Horizon 2020.
Endocrinologists are at the heart of solving the most pressing health problems of our time, from diabetes and obesity to infertility, bone health and hormone-related cancers. The Endocrine Society is the world's oldest and largest organization of scientists dedicated to hormone research and doctors who treat people with hormone-related disorders.
The Society has more than 18,000 members, including scientists, doctors, educators, nurses and students from 122 countries. To find out more about the Company and the field of endocrinology, visit our website at http://www.nrc.gov.on.ca.
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