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This is the first evidence to suggest that bacterial changes in the tongue could be an early indicator of pancreatic cancer.
Early diagnosis of pancreatic cancer improves chances of treatment success
Washington D.C .: According to the results of a new study published in the Journal of Oral Microbiology, the different types of bacteria living on the tongue can distinguish patients with early pancreatic cancer from healthy individuals.
This is the first evidence to suggest that bacterial changes in the tongue could be an early indicator of pancreatic cancer. If confirmed by larger studies, this could pave the way for the development of new early warning or life-saving prevention tools to save this very aggressive disease.
An early diagnosis of pancreatic cancer can dramatically improve the chances of successful treatment – but this poses problems for this condition as it develops deep in the body and often has few symptoms before it has already spread . As a result, most patients already have advanced illness when they seek medical help.
While researchers are looking for biological modifications to accurately detect the early signs of pancreatic cancer, the potential role of the microbiome in cancer development is a hot topic. Previous studies have already shown dramatic disturbances of bacteria in saliva, intestinal and stool samples taken from patients with pancreatic cancer compared to healthy individuals.
In the first study aimed at characterizing the microbiome of the tongue in patients with pancreatic cancer, a team of researchers recruited a group of 30 patients with early-stage disease (diagnosed with a tumor positioned in the region of the "head" of the pancreas) and the like. group of 25 people in good health.
Participants were all between the ages of 45 and 65, had no other diseases or oral health problems and had not taken any antibiotics or other medications in the three months prior to the study.
The research team used gene sequencing technologies to examine the microbiomic diversity of language coat samples and found that patients with pancreatic cancer were colonized by microbiomes extremely different from the language coating compared to healthy individuals.
Speaking of which, the main author Lanjuan Li said: "Although further confirmatory studies are needed, our findings add to the growing evidence of an badociation between disturbances of the microbiome and pancreatic cancer. "
Notably, the abundance of four types of bacteria – low levels of Haemophilus and Porphyromonas and high levels of Leptotrichia and Fusobacterium – could distinguish patients with pancreatic cancer from individuals in healthy.
The research team hypothesizes that the immune system is most likely a link between confirmed changes in the microbiome and pancreatic cancer. They theorize that the development of the disease in the pancreas can influence the immune response to promote the growth of certain bacteria – or vice versa. If proven, this could pave the way for the development of new treatment strategies using antibiotics or immunotherapies – or even probiotics that may contribute to the prevention of pancreatic cancer in patients with high risk.
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