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Reading has won only one of their six matches since Jose Gomes took charge of the teamFollow the live text broadcast on Tuesday from 19:30 GMT
Defenders Bolton, David Wheater, Marc Wilson and Jonathan Grounds are all doubtful for the match against Reading.
Wheater is injured in the knee, Wilson is recovering from a dead leg and Granee Grounds missed Bristol City's defeat of the FA Cup due to illness.
Reading will almost certainly be without defender Tiago Ilori, who should leave the club.
The loan signatures Nelson Oliveira, Emiliano Martinez and Matt Miazga are available and hope to make their debut.
Match facts
After a 1-0 first-leg victory this season, Bolton is looking to register his first league-double against Reading since 2007-08, when they were both in the Premier League.
Reading is undefeated in Bolton in their last four league games (W1 D3) and came back 2-0 tied 2-2 at this game last season.
Bolton has kept only one clean sheet in his last 20 games in all competitions (W2 D4 L14).
Reading has won only once in their last 23 games away, in all competitions (D8 L14).
Bolton has only attempted 37 shots in home league games this season – only Ipswich has had fewer (36).
Six of the seven goals conceded by Reading to the Championship under the guidance of Jose Manuel Gomes were scored in the first half and none after the 48th minute.
Source: bbc.com
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