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<div data-thumb = "https://3c1703fe8d.site.internapcdn.net/newman/csz/news/tmb/2019/1-movingtarget.jpg" data-src = "https: //3c1703fe8d.site.internapcdn. net / newman / gfx / news / 2019/1-movingtarget.jpg "data-sub-html =" Researchers at Walter and Eliza Hall Institute have developed a new imaging technique to visualize the key steps in the process. Evolution of cancer cells in tumors, potentially revealing Breast cancers escape treatment, which has also been used to reveal the complex structure of bad ducts, part of the human bad.Richard: Rios, Visvader et al. published in Cancer cell">
Researchers at the Walter and Eliza Hall Institute have developed a new imaging technique to visualize key steps in the evolution of cancer cells within tumors, potentially revealing how bad cancer escapes treatment . This has also been used to reveal the complex structure of the bad ducts, part of the human bad. Credit: Rios, Visvader et al., Posted in Cancer cell
Researchers at the Walter and Eliza Hall Institutes have developed a new imaging technique to visualize key steps in the evolution of tumor cells within tumors, potentially revealing how bad cancers escape treatment.
Using a bad cancer laboratory model, researchers were able to visualize tumors in three dimensions, at a previously unreachable resolution. This has revealed how cancer cells grow from precancerous cells in the bad ducts and changes that occur in the tumor over time.
The research, which was published today in the journal Cancer cell, suggests that bad cancer cells are inherently changing from one type of cell to another at the molecular level – resembling cells more likely to spread.
See the evolution of cancer cells
Transformation of normal mammary gland cells into cancer cells occurs at several stages, with "precancerous" cells becoming early-stage cancer cells, which can then undergo changes that make cells more likely to dissociate from the tumor. . Until now, it was not possible to visualize individual clones – "sister" cells descending from a single precancerous cell – into an entire tumor.
Imaging technology has allowed the research team to examine the frequency of precancerous cells that develop into tumors in the mammary gland and attack cell behavior at the same time. 39, tumors inside. The study was led by Dr. Anne Rios, with Professors Jane Visvader and Geoff Lindeman from the Walter and Eliza Hall Institute.
"Using a new imaging technique, we revealed that only a small proportion of precancerous cells would become tumors," said Professor Visvader. "On the other hand, once a tumor was formed, we discovered that it was very likely that its cells would undergo what is called an" epithelial-mesenchymal transition "(EMT). is a change in the "molecular landscape" – the genes activated or deactivated – inside the cell, transforming it from an "epithelial" form into a "mesenchymal" form "which may have an advantage in terms of growth.
"Our models suggest that EMT is not a rare event, but is an inherent feature of bad tumor cells."
The results were obtained in laboratory models much like human bad cancer, and the team suspects that bad cancers in humans are also likely to present a high rate of molecular MTCT, said Professor Lindeman, medical oncologist at the Royal Melbourne Hospital. Peter MacCallum Cancer Center.
"If electromagnetic cancers are common in bad cancer, it means that cells are a" moving target. "They can escape a set of weapons we have available to fight cancer, which means we need to develop more targeted strategies, "said Professor Lindeman. .
A new imaging technique allowed our researchers to visualize tissues and tumors at high resolution, which was previously impossible. This image shows the three-dimensional structure of the mammary ducts of human bad tissue. Credit: Rios, Visvader et al, Cancer Cell.
New views on tumors
A new three-dimensional imaging technique was essential for discoveries, said Dr. Rios, who now works at the Princess Maxima Center for Pediatric Oncology in the Netherlands.
"Until now, it was difficult to visualize complex structures of complex tissues such as bad tissue, or to see the true arrangement of cells in tumors," said Dr. Rios. "We have developed a new fast way to prepare tissue samples that retain their complex architecture but allows us to distinguish between individual cells and the three-dimensional structure of the tissue.
"Our method allowed us to capture unpublished images of mammary and bad tissue tumors and it was crucial for us to discover the frequency of TUM in tumors.
"We anticipate that our new imaging method will use many other applications to study normal and cancerous tissue samples," said Dr. Rios.
'Cellular barcode' reveals how bad cancer spreads
Cancer cell (2019). DOI: 10.1016 / j.ccell.2019.02.010, https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30105-9
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Breast cancer cells "mobile targets" revealed by a new imaging technique (March 28, 2019)
recovered on March 28, 2019
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