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Kahweol acetate and cafestol, two hydrocarbons present in Arabica coffee, have shown the potential to delay the growth of prostate cancer in mice. Researchers are now studying the possibility of using compounds to prevent the development of cancer in humans. ( Elias Shariff Falla Mardini | pixabay )
Drinking a cup of coffee regularly could help prevent the development of prostate cancer in men, according to a new study by Japanese researchers.
In an article in the newspaper Prostate, scientists from Kanazawa University in Japan have discovered the potential of two compounds found in coffee to inhibit the growth of prostate cancer.
Coffee is known to have both positive and negative effects on human health. One of these potentials is its ability to reduce the occurrence of certain malignancies, especially prostate cancer.
That's what Hiroaki Iwamoto, a researcher at the KU Graduate School of Medical Science, and his colleagues decided to explore in their pilot study.
Benefits of coffee against prostate cancer
Iwamoto and his team first identified six compounds found naturally in coffee to determine their impact on the growth of cancer cells in the prostate. As their research progressed, they were limited to two specific compounds: kahweol acetate and cafestol.
The researchers tested the compounds on laboratory mice transplanted with prostate cancer cells. They then divided the animals into four groups, one group treated with kahweol acetate, one group of cafestol, one group of kahweol acetate and cafestol and another group serving as control.
The team found that prostate cancer in mice treated with a combination of kahweol acetate and cafestol had a much slower growth than those who had not received any treatment.
After 11 days of testing, the tumor of animals receiving both compounds increased by only one and a half times, or 167% of their original size.
At the same time, the tumors of those who received none of these compounds grew about three and a half times, or 342% more than their initial size.
Kahweol acetate and cafestol helped to retard the growth of malignant cells known for their high resistance to anticancer drugs.
Test of the impact of coffee compounds on human patients
Although the results are promising, it is important to note that the pilot study serves only to prove that kahweol acetate and cafestol both have the ability to prevent prostate cancer .
Iwamoto and his colleagues said more research was needed to further investigate the potential impact of coffee compounds on human cancer growth. They are already studying the possibility of conducting the study on larger samples and then on human patients.
Kahweol acetate and cafestol are naturally occurring hydrocarbons in Arabica coffee beans. However, the amount of compounds in a cup of coffee sometimes depends on how the beverage is prepared. The infusion allows a greater amount of kahweol acetate and cafestol to stay in the drink, while the filtering tends to remove them from the coffee.
Despite the potential benefits of coffee consumption on prostate cancer, study co-author Atsushi Mizokami said their findings should not lead people to change the way they consume the drink. .
"Coffee can have both positive and negative effects (for example, it can increase hypertension), so we need to know more about the mechanisms behind these findings before we can think of clinical applications. "said Mizokami.
"However, if we can confirm these results, we could have candidates to treat drug-resistant prostate cancer."
Researchers around the world are exploring the potential of existing foods and beverages to prevent the development of certain diseases.
Earlier this month, US scientists have identified compounds found in green tea and carrots that help combat the degenerative effects of Alzheimer's disease and dementia.
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