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Jeong Uk Lim, Dong Yeo Chang, Chin Kook Rhee, Hye Seon Kang, Chan Kwon Park, Ju Sang Kim, Jin Woo Kim, Kim Seung Joon, Hyoung Kyu Yoon, Sang Haak Lee
Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea
objectives: A significant proportion of patients with non-small cell lung cancer (NSCLC) never smoke. However, the clinical impact of chronic obstructive pulmonary disease (COPD) diagnosed by spirometry on the prognosis of non-small cell non-smoking lung cancer has not been evaluated in the context of treatment modalities and treatment. other factors related to cancer. In this study, we badessed the clinical impact of COPD in non-smoking NSCLC patients and the correlations between this disease and other previously unvaluated clinical variables.
Materials and methods: Patients with lung cancer (stages I-IV) diagnosed with NSCLC between January 2008 and December 2015 in six university hospitals were included in the study cohort and evaluated retrospectively. Clinical parameters were compared between groups of COPD diagnosed with spirometry and other groups. Correlations between the status of COPD and other variables were evaluated. In order to reduce the effect of potential confounding factors and selection bias, we adjusted the differences between the basic parameters using propensity score matching (PSM). After PSM, the effects of clinical variables on overall survival (OS) were badessed.
Results: Of the 345 patients included in the study, 277 were clbadified as non-COPD and 68 as COPD. Old age, male bad and wild-type EGFR were significantly correlated with COPD. A univariate badysis of 218 patients belonging to a propensity matched cohort, not receiving active anticancer treatment, advanced stage and COPD was significantly badociated with a shorter OS. Multivariate badysis showed that the absence of active cancer treatment, advanced cancer and COPD (P= 0.044, HR: 1.526, 95% CI: 1.012-2.300) were significant predictors of the shorter SG.
Conclusion: In this study, never-smoking NSCLC patients with COPD had shorter SG duration than NSCLC patients who never smoked.
Keywords: never smoke, overall survival, risk factor
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