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A recent study found that the mode of delivery affected the health of infants. The research presented at the ECCMID 2019 meeting suggested that the mode of delivery influences the development of the microbial composition of the intestine (that is, the gut microbiota) in infants regardless of the use of antibiotics by the mother. This, in turn, can affect the respiratory health of infants during the first year of life.
The upcoming Utrecht Microbiome Infant Study of 120 infants revealed that children born by caesarean section had a delay in the normal development of their gut microbiota and a greater abundance of potentially harmful bacteria, compared to infants delivered badlly. could be the mechanism causing the increased risk of respiratory infections.
More than 1000 different types of bacteria live in the intestine, where they have important health functions, for example by helping to digest food, stimulating the development of the immune system and protecting against infections. . After birth, babies are colonized by an increasing diversity of intestinal microbes until they reach a relatively stable state. The pace and rate at which infants acquire their intestinal microbiome is thought to have a considerable impact on health at a later age. Disruption of the normal development of the intestinal microbiome has been badociated with various diseases, including irritable bowel disease, asthma, allergies and cancer.
Previous research has shown that birthing mode influences the development of microbiota at the beginning of life, but it has been suggested that this mainly depends on the exposure of antibiotics by the mother. To evaluate the independent effects of delivery mode badyzed the development of gut microbiota in 46 c-sectioned infants and 74 badl-delivered infants with the help of stool samples taken 10 times in their first year of life. The administration of antibiotics to mothers undergoing cesarean section was postponed after clamping the umbilical cord. Samples of maternal stools were also examined two weeks after delivery.
The badyzes showed that the composition of the gut microbiota was significantly different between caesarean infants and badl deliveries in the first year, which was more pronounced shortly after birth. This accompanied a measurable fecal seeding (transfer of maternal badl microbes) from mother to child in badl-delivered infants, but not in children born from a caesarean section. . Bacterial species favorable to health, Bifidobacterium spp. In addition, infants born by cesarean section had significantly higher rates of potentially pathogenic intestinal bacteria, regardless of the duration of hospitalization after birth, the type of infants born by caesarean section. diet and the use of antibiotics. Interestingly, researchers also found that the intestinal microbiota at the beginning of life was badociated with the total number of respiratory infections during the first year.
"Our results suggest that delivery mode affects the infant's developing gut microbiota, regardless of the mother's use of antibiotics at birth. Compared to badl delivery infants, children born by cesarean section follow different pathways of bacterial colonization, which could have implications for their future respiratory health, "said Marta Reyman, PhD student in this study. Consequences of these changes: The knowledge gained could help design strategies to prevent health problems after cesarean birth, Reyman added.
The main limitation of this study is the use of 16S rRNA-based sequencing, which does not allow the annotation of bacteria at the species level or generates results based on the genetic content of microbial communities. .
Posted: 13th April 2019 at 13:48
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