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In humans, glucose is the main sugar of energy-intensive cells in the brain, muscles and peripheral neurons. Any deviation from normal blood glucose for a prolonged period can be dangerous or even fatal; therefore, the regulation of blood glucose is a biological imperative. Previous research has shown that the vagus nerve, which connects to many major organs of the body and communicates its changes to the brainstem, plays a role in regulating metabolism. Since the details of how this was accomplished were largely unknown, Dr. Zanos and his colleagues sought to identify the specific signals relayed from the periphery to the brain that responded to changes in blood glucose. By deciphering these signals, they can better understand when and how to stimulate the vagus nerve to regulate metabolism.
"One of our goals is to understand the neural code of the vagus nerve when it is related to different conditions, because we believe that by listening to and stimulating this nerve, we can open up new possibilities. to diagnose and treat various diseases, "said Dr. Zanos. . "The vagus nerve is one of the main information channels of the body with an average of 100,000 nerve fibers, making this code difficult to grasp and decipher, so we have a lot to learn. the latter study that the vagus nerve of a mouse carries important signals from the periphery to the central nervous system related to glucose homeostasis – this discovery brings us closer to new technologies that could help many patients with various metabolic diseases. "
Dr. Zanos collaborated on this study with researchers from the Feinstein Institutes. Emily Battinelli Masi, PhD, Todd Levy, MRS, Tsaava tea, MD, Chad E. Button, MS and Sangeeta S. Chavan, PhD. The article, titled "Identification of specific neuronal signals of hypoglycemia by decoding the activity of the badl nerve wave", was also co-author of the article, was president and chief from the direction of Feinstein Institutes Kevin J. Tracey, MD.
"This discovery by Dr. Zanos and our researchers in bioelectronic medicine allows us to better understand the neural signaling of the body and offers hope for the management of diabetes," said Dr. Tracey.
Bioelectronic Medicine is a new approach to the Feinstein Institutes' laboratories to treat and diagnose diseases and injuries. It represents a convergence of molecular medicine, neuroscience and bioengineering. Bioelectronics medicine uses device technology to read and modulate electrical activity in the body's nervous system, opening new doors to real-time diagnosis and treatment options for patients.
Last year, Dr. Zanos and his collaborators were the first to decode the specific signals used by the nervous system to communicate immune status and inflammation to the brain. The identification of these neuronal signals and what they communicate about the health of the body has been a step forward for bioelectronic medicine, as it has helped to better understand the diagnostic and therapeutic targets and the device development. These results were published in Proceedings of the National Academy of Sciences (PNAS).
About Feinstein Institutes
Feinstein Medical Research Institutes is the research arm of Northwell Health, the largest health care provider and private employer of New York. Home to 50 research laboratories, 2,500 clinical studies and 4,000 researchers and employees, the Feinstein Institutes raise the level of medical innovation through its five institutes (behavioral sciences, bioelectronic medicine, cancer, innovations and results). in health and molecular medicine). We are making inroads in the areas of genetics, oncology, brain research, mental health, autoimmunity and bioelectronic medicine – a new scientific field that is likely to revolutionize medicine. For more information on how we produce knowledge to cure diseases, visit feinstein.northwell.edu.
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Emily Ng |
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SOURCE Feinstein Medical Research Institutes
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