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Through staff reports
LOS ANGELES (CNS) – According to a USC study released Monday, the early onset of Alzheimer's disease early in Alzheimer's disease depends on its capillary capillarity.
The findings, which appear in the current issue of Nature Medicine, could help earlier diagnosis and suggest new targets for drugs that may slow down or prevent the onset of the disease, according to the researchers.
According to the US Center for Disease Control and Prevention, the number of Americans with Alzheimer's disease is expected to more than double to reach about 14 million in 40 years. There are currently five Alzheimer's drugs approved by the US Food and Drug Administration that temporarily alleviate memory and thinking problems, but none address the underlying cause of the disease or slow its progression. The researchers believe that a successful treatment will eventually involve a combination of drugs targeting multiple targets.
USC's five-year study of 161 older adults showed that memory loss from the brain's blood vessels was also affected by people with the most severe memory problems, regardless of the presence of protein. abnormal, amyloid and tau protein.
"The fact that we are witnessing leakage of blood vessels, regardless of tau and amyloid, when people have mild cognitive impairment, suggests that it could be an effect of totally separate process or a very early process, "said lead author Berislav. Zlokovic, director of the Zilkha Neurogenetic Institute at the Keck School of Medicine of the USC. "It was surprising that this disruption of the blood-brain barrier occurred independently."
In healthy brains, the cells that form the blood vessels fit together so tightly that they form a barrier that prevents unwanted cells, pathogens, metals and other unhealthy substances from reaching brain tissue. Scientists call this the blood-brain barrier. In some aging brains, the joints between the cells relax and the blood vessels become permeable.
"If the blood-brain barrier does not work properly, there is a risk of harm," said Arthur Toga, co-author, director of the USC Stevens Institute of Neuroimaging and Computer Science at the Keck School of Medicine. "This suggests that the vessels are not providing the nutrients and blood flow the neurons need, and you have the possibility that toxic proteins will enter the body."
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