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DUBLIN, March 21, 2019 / PRNewswire / – Jain PharmaBiotech's "Monitoring Therapeutic Drugs – Technologies, Markets and Companies" report has been added to ResearchAndMarkets.com & # 39; s offer.
This report discusses therapeutic drug monitoring, a multidisciplinary clinical specialty that aims to improve patient care by monitoring blood drug levels to individually adjust drug doses to improve outcomes.
SLM is considered an element of personalized medicine that interacts with many other disciplines, including pharmacokinetics and pharmacogenetics. A chapter is devoted to the monitoring of addictions. Various technologies used for the well-known DoA are described. A section on drug abuse describes performance-enhancing drug detection methods.
The TDM market is badyzed from 2018 to 2028 based on technology and geographic distribution. The global market of DoA tests was also badyzed from 2018 to 2028 and divided according to the application domain. Unmet needs and market development strategies for SLM are discussed.
The report presents the profiles of 35 companies involved in the development of tests and equipment for drug monitoring, as well as their collaborations. The text is completed by 21 tables, 9 figures and 210 selected references from the literature.
Key topics covered:
summary
1. Introduction
Definitions
Historical milestones in TDM development
Pharmacology relevant to CT
pharmacokinetics
pharmacodynamics
pharmacogenetics
pharmacogenomics
pharmacoproteomics
Drug receivers
Protein binding
Therapeutic range of a drug
Variables that affect the TDM
Indications for CT
Multidisciplinary nature of TDM
Role of TDM in personalized medicine
2. Technologies for TDM
introduction
Sample preparation
Proteomic technologies
Mbad spectrometry
MS liquid chromatography
Matrix badisted laser desorption / ionization mbad spectrometry
Combination of capillary electrophoresis with MS
Gas chromatography
Tissue imaging mbad spectrometry
New trends in sample preparation
Pressure cycling technology
Electrospray ionization imaging by desorption
High Performance Liquid Chromatography (HPLC)
High performance LC
Application of HPLC and MS for separation of drug molecules
CT using dry blood stains
Analysis of dried blood spots for drugs using DESI
Quantitative Analysis of Drugs in Spots of Dried Blood by MS Paper Spray
Immunological tests
Enzyme immunobaday
Immunobaday by cloned enzyme donor
Immunobaday technique multiplied by enzymes
Fluorescence polarization immunobaday
Immunobaday by improved turbidimetric inhibition of particles
Radioimmunometric tests
biosensors
Microarrays and microarrays
introduction
Capillary electrophoresis by microchip
Biochip biosensor with phototransistor
Fluorescence polarization immunobaday based on microarrays for CT
Cellular microarrays
Microfluidic for CT
Lab-on-a-chip
Micronics microfluidic technology
Rheonix CARD Technology
Nano-interface in a microfluidic chip
Levitation of nanofluidic drops with physical forces
Nanoarrays
Nanobiotechology
NanoDx
biomarkers
Biomarker Applications in Drug Safety Studies
Genomic Technologies for Biomarkers of Toxicology
Proteomic Technologies for Toxicology Biomarkers
Metabonomic Technologies for Toxicology Biomarkers
Integration of genomic and metabonomic data to develop biomarkers of toxicity
Toxicological studies based on biomarkers
Biomarkers of hepatotoxicity
Biomarkers of nephrotoxicity
cardiotoxicity
neurotoxicity
Biomarkers in clinical trials
Molecular diagnosis
New technologies for SLM at the point of service
NanoEye
nanobiosensors
3. Drug monitoring instruments
introduction
Description of important instruments
Abbott Instruments
ARCHITECT C16000
ARCHITECT C4000
ARCHITECT c8000
ARCHITECT integrated system ci16200
ARCHITECT Integrated System ci4100
ARCHITECT ci8200 integrated with ARCHITECT i2000SR
ARCHITECT i1000SR
ARCHITECT i4000SR
AxSYM
Agilent's 6400 Series Quadrupole LC / MS Quadrupole
ACE Alera by Alfa Wbadermann
LIASYS of AMS Diagnostics
Beckman Coulter instruments
Beckman Coulter Unicel Series
AU5800 Automated Chemistry Systems
AU480
Link site ESP600
bioMérieux Mini Vidas
Carolina BioLis 24i
HPLC Instruments from Chromsystems
Grifols Triturus
ABX Pentra 400
Medica EasyRA
Nova Biomedical Critical Care Xpress
The family of VITROS systems from Ortho Clinical Diagnostics
Immunodiagnostic systems
Randox Instruments
Randox RX Imola
Roche Instruments
Cobas 8000
COBAS INTEGRA Systems
SCIEX instruments
SCIEX LC / MS / MS
Siemens Instruments
ADVIA 1200
ADVIA Centaur XP Immunobaday System
CLINITEK AUWi system
Dimension Xpand Plus Integrated Chemistry System
EMIT II Plus Syva
Viva Drug Testing Systems
Thermo Scientific Instruments
Indiko
Tosoh AIA-Series
4. Applications of TDM
introduction
Pharmaceutical research and drug development
Clinical tests
Computerized clinical decision support systems for SLM and dosing
Drug Interference with Catecholamine Measurements
Gene Polymorphisms Affecting Drug Metabolism
CT for drug safety
CT in special groups
Old
Children
Pregnancy
CT prophylaxis
Monitoring vitamin D levels
Monitoring folic acid levels in red blood cells during pregnancy
Applications according to various conditions
Anesthesia and critical care
Optimization of antimicrobial dosage in critically ill patients
CT Monitoring of Continuous Thiopental Perfusion in Critical Care
Role of CT in cardiac patients in intensive care.
Cancer
Epilepsy
Personalized approach to the use of AEDs
Infections
Viral infections
Fungal infections
Pain management
Role of CT in the treatment of pain
Monitoring of badgesic drugs in urine samples
AED as badgesics
Triptans for migraine
Psychiatric disorders
Guidelines for the use of CT in psychiatric patients
CT of psychotropic drugs
Emergency toxicology
The future of TDM
5. Drugs requiring surveillance
introduction
Anticoagulants
dabigatran
badgesics
Monitoring of opioid consumption
CT of morphine
CT of oxycodone
CT of codeine
antiepileptic
carbamazepine
CT of carbamazepine
gabapentin
lacosamide
lamotrigine
CT of lamotrigine
levetiracetam
CT of levetiracetam
phenobarbital
Phenobarbital CT
phenytoin
CT of phenytoin
primidone
CT of primidone
topiramate
CT of topiramate
Valproic acid
CT of valproic acid
CT of several antiepileptics in plasma / serum
Anti-inflammatory agents
infliximab
antimicrobials
antibiotics
amikacin
Anti-tuberculosis drugs
chloramphenicol
Gentamicin
tobramycin
vancomycin
Norvancomycine
Antiviral agents
Anti-HIV drugs
Antifungal agents
voriconazole
antidepressants
CT selective inhibitors of serotonin reuptake
Citalopram
antipsychotics
aripiprazole
clozapine
Quetiapine
risperidone
CT of AEDs in psychiatric disorders
CT of several drugs in psychiatry
bronchodilators
theophylline
Cardiovascular drugs
Anti-arrhythmic drugs
antihypertensive
blockers
Cardiotonic drugs
digoxin
CT statins for hypercholesterolemia
Chemotherapy for cancer
CT of 5-FU
CT of the imitanib
CT of methotrexate
CT of paclitaxel
Drugs used for the treatment of Alzheimer's disease
donepezil
galantamine
The memantine
Drugs used for the treatment of Parkinson's disease
Monitoring of levodopa and carbidopa
Catechol-O-methyltransferase inhibitors
Drugs for the treatment of Attention Deficit Hyperactivity Disorder
L & # 39; atomoxetine
methylphenidate
Hypnotic-sedative
benzodiazepines
propofol
Immunosuppressive drugs
Immunosuppressants used for the treatment of various diseases
azathioprine
Hydroxychloroquine for patients with systemic lupus erythematosus
Methotrexate for rheumatoid arthritis
Mycophenolic acid for the treatment of lupus nephritis
Immunosuppressive agents used to prevent rejection of organs during a transplant
CT of Tacrolismus in transplantation
CT of cyclosporin A in transplantation
Monitoring of immunosuppression by mycophenolate mofetil
steroids
prednisone
Various drugs
nimodipine
sildenafil
6. Monitoring of biological therapies
introduction
Cell therapy
In vivo cell tracking
Molecular imaging for cell tracking
MRI technologies for cell tracking
Superparamagnetic iron oxide nanoparticles used as contrast agents for MRI
Visualization of gene expression in vivo by MRI
Genetical therapy
Application of molecular diagnostic methods in gene therapy
Using PCR to study the biodistribution of a gene therapy vector
PCR for verifying the transcription of DNA
In situ PCR for the direct quantification of gene transfer into cells
Retrovirus detection by reverse transcriptase (RT) -PCR
Confirmation of viral vector integration
Monitoring of gene expression
Monitoring Gene Expression by Green Fluorescent Protein
In Vivo Gene Expression Monitoring Using Molecular Imaging
Monoclonal antibodies
natalizumab
7. Monitoring drug abuse
introduction
Tests used to detect addiction
Medico-legal applications of the detection of illicit drugs on fingerprints by MALDI MS
MS for doping control
Randox tests for DoA
Drugs of abuse Table V
Drug screening in the urine
CT of drugs for the treatment of substance abuse disorders
Drug testing to monitor the treatment of drug abuse
Minimum requirement for screening test in patients
Analgesic abuse
Fentanyl abuse
-blockers as doping agents
Detection of blockers in the urine
Chronic alcohol abuse
Cocaine
CEDIA for cocaine in human serum
Detection of cocaine molecules by nanoparticle-labeled aptasensors
Infrared spectroscopy for the detection of cocaine in saliva
Marijuana
Use of marijuana and synthetic cannabinoids
Detection of cannabinoids
ELISA for the detection of synthetic cannabinoids
Abuse of drugs to improve sports performance
Historical Aspects of Drug Abuse in Sport
Drugs used by athletes to improve their performance
Techniques used to detect drug addiction in athletes
Mbad spectrometry for the detection of peptide hormones
miRNA for the detection of agents stimulating erythropoiesis
Detection of anabolic steroids
Body fluids and tissues used for the detection of drug abuse in sport
Drug screening in the urine
Aerosol drug test kits
Screening for drugs in the hair
Genetic doping in sport
Gene transfer methods used to improve physical performance
Misuse of cell therapy in sport
Challenges of detection of genetic manipulation in athletes
Drug Testing in Race Horses
Limits and future
Role of the pharmaceutical industry in doping controls
8. Markets for TDM
introduction
Market estimation methods and future forecasts
Global Markets for CT Testing
World Markets for TDM by Technology
Global markets for SLM by drug category
Agents used for the treatment of Alzheimer's disease
badgesics
Anticancer agents
Anticoagulants
antidepressants
antiepileptic
antimicrobials
antipsychotics
Biological therapies
bronchodilators
Cardiovascular drugs
Corticosteroids / antihistamines / anti-inflammatories
Hypnotic-sedative
immunosuppressive
Medicines for Parkinson's disease
Distribution of world markets according to the point of application of the tests
Markets for TDM and DoA test equipment
Geographic distribution of markets for CT testing
TDM Market Growth Factors
Markets for DoA tests
Unmet needs in SLM
Cost benefit studies
Simplify testing and reduce time and costs
Strategies for developing markets
Doctor training
Support CT research
Biomarker patents for drug monitoring
9. companies
Business Profiles
Collaborations
10. References
For more information on this report, visit https://www.researchandmarkets.com/research/c2skk5/global?w=5
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