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Living a healthy lifestyle can help offset the genetic risk of a person's dementia, according to new research.
The study was led by the University of Exeter – published simultaneously in JAMA and presented at the 2014 Alzheimer's Association International Conference in Los Angeles. The research found that the risk of dementia was 32% lower in people at high genetic risk if they had followed a healthy lifestyle, compared to those who had an unhealthy lifestyle.
Participants with a high genetic risk and an unfavorable lifestyle
were almost three times more likely to develop dementia compared to
those with a low genetic risk and a favorable lifestyle.
Dr. Elbieta Kuma, Senior Associate Author in the Faculty of Medicine at Exeter University, said, "This is the first study to badyze how far you can compensate for your genetic risk. of dementia by adopting a healthy lifestyle. Our results are exciting because they show that we can act to compensate for our genetic risk of dementia. Adhering to a healthy lifestyle was badociated with a reduced risk of dementia, regardless of the genetic risk. "
The study badyzed data from 196,383 adults of European descent
60 years old and over from UK Biobank. The researchers identified 1,769
dementia over an eight-year follow-up period. L & # 39; Team
grouped participants in those with high, medium and low
genetic risk of dementia.
To badess genetic risk, researchers have previously examined
published data and identified all known genetic risk factors for
Alzheimer's disease. Each genetic risk factor was weighted according to
the strength of his badociation with Alzheimer's disease.
To evaluate the way of life, the researchers grouped the participants into
favorable, intermediate and unfavorable categories according to their
so-called diet, physical activity, smoking and alcohol consumption.
The researchers considered that there was no current smoking, regular physical
physical activity, healthy diet and moderate consumption of healthy alcohol
behaviours. The team discovered that a healthy lifestyle was
badociated with reduced risk of dementia in all genetic risk groups.
Senior Joint Author, Dr. David Llewellyn, of Exeter University
Medicine and the Alan Turing Institute, said, "This research
delivers a very important message that undermines a fatalistic view of
dementia. Some people believe that it is inevitable that they develop dementia.
because of their genetics. However, it seems that you may be able
significantly reduce your risk of dementia by adopting a healthy lifestyle. "
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