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Jennita Reefhuis
American counties with high opioid prescribing rates have 1.5 times more babies born with gastroschisis, a serious conbad abnormality of the abdominal wall, than counties with a low opioid prescription rate , according to a study published in MMWR.
"This report is a signal for further research on overall findings after in utero exposure to opioids, including conbad anomalies, [neonatal abstinence syndrome]but also longer-term results ", Jennita Reefhuis, PhD, Head of the Conbad Anomalies Division of CDC's National Center for Birth Defects and Developmental Disorders Infectious Diseases in Children.
In their report, Reefhuis and his colleagues wrote that "gastroschisis requires surgical repair after birth and is badociated with digestive and nutritional complications during early childhood, which can be detrimental to development."
They also reported that recent data from 14 US states indicated an increase in the prevalence of gastroschisis between 1995 and 2012.
The researchers examined annual data from 20 population-based conbad anomaly surveillance programs aimed at measuring the prevalence of gastroschisis between 2006 and 2015. The data were divided into two periods: 2006-2010 and 2011-2015. They compared the annual prevalence of gastroschisis by categories of annual prescription opioid rates.
They reported 3,489 gastroschisis cases among 8,342,741 live births between 2006 and 2019 (4.2 per 10,000 live births) and 4,166 out of 9,359,005 live births between 2011 and 2015 (4.5 per 10,000 births). living).
The prevalence of gastroschisis was highest among infants born to mothers under 20; However, a linear increase in prevalence has been observed in older mothers.
The researchers wrote that between 2005 and 2015, the prevalence of gastroschisis was 1.6 times higher in countries with high opioid prescription rates (5.1 per 100 live births) and 1.4 higher with average prescription rates (4.6 per 10,000 live births) compared to regions with lower prescribing rates (3.2 per 10,000 live births).
"This ecological badysis corroborates the findings of a large, case-controlled study, which suggested that the use of self-reported prescription opioids during the first trimester was badociated with gastroschisis," wrote the authors. researchers.
Reefhuis has urged women who are pregnant or likely to be and likely to have been exposed to opioids to talk to a health care provider.
She stated that the CDC, the Administration of Addiction and Mental Health Services and the American College of Obstetricians and Gynecologists "consider drug-badisted treatment as the best practice in the management of pregnant women with a disorder of the use of opioids. It is important for health care providers to work closely with pregnant women to carefully manage the medical care she and her baby provide during pregnancy and after delivery. The coordination of care between OB-GYN, pediatricians and addiction specialists is very important for the well-being of the mother and the baby. "- by Bruce Thiel
Disclosures : The authors do not report any relevant financial information.
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