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This approach reduces seizures by 93% in three months
A protein-secreting device implanted in the hippocampus of epileptic rats reduces seizures by 93% in three months, according to a preclinical study published in JNeurosci. These findings support the ongoing development of this technology and its potential translation into a new treatment for epilepsy.
Giovanna Paolone and her colleagues at the University of Ferrara, Italy, and Gloriana Therapeutics, Inc. (Providence, RI), motivated by an unmet need for effective and well-tolerated epilepsy treatments, studied the effects of gloriana targeted cell delivery system for glial cells. Neurotrophic factor derived from a lineage (GDNF) – a protein suggested by a recent study could help suppress epileptic activity.
In addition to rapidly and progressively reducing seizures in male rats – by 75% in two weeks – researchers found that their device improved anxiety-like symptoms and their performance at a recognition task. object, indicating an improvement in cognition.
The treatment also corrected anomalies of cerebral anatomy badociated with epilepsy. These effects persisted even after the removal of the device, indicating that this approach could alter the progression of the disease.
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