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January 30, 2019
With intensive BP control, significant reductions in the risk of mild cognitive impairment have been observed.
HealthDay News – According to a study published online Jan. 28, treating systolic blood pressure (BP) at a target below 120 mm Hg rather than at 140 mm Hg does not result in a significant reduction in blood pressure. risk of probable dementia. Journal of the American Medical Association.
Jeff D. Williamson, MD, MHS, of the Wake Forest School of Medicine in Winston-Salem, North Carolina, and colleagues randomly badigned to adults aged 50 or older with hypertension with a goal systolic BP <120 mm Hg (4,678 participants) or <140 mm Hg (4,683 participants).
The trial was stopped prematurely to obtain a benefit on its primary endpoint (composed of cardiovascular events) and on all-cause mortality. The researchers found that the probable dementia badessed was found in 149 and 176 participants in intensive and standard treatment groups, respectively, during a median follow-up of 5.11 years (7.2 vs. 8, 6 by 8.6 years, risk ratio 0.83, 95% confidence interval, 0.67 to 1.04).
With intensive BP control, the risk of mild cognitive impairment was significantly reduced (14.6 versus 18.3 per 1000 person-years, 0.81 risk ratio, 95% confidence interval of 0 , 69 to 0.95) and the combined rate of mild cognitive impairment. and probable dementia (20.2 vs. 24.1 cases per 1,000 person-years, hazard rate 0.85, 95% confidence interval 0.74 to 0.97).
"These results show importantly that an intensive control of blood pressure did not interfere with cognition," the authors write. "In addition, some clues suggest that an intensive blood pressure control could be beneficial."
Several authors have revealed financial links with pharmaceutical companies, including Takeda Pharmaceuticals, which provided drugs for the study.
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